3hmf: Difference between revisions

<StructureSection load='3hmf' size='340' side='right'caption='[[3hmf]], [[Resolution|resolution]] 1.63&Aring;' scene=''>

<table><tr><td colspan='2'>[[3hmf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HMF FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hmf OCA], [https://pdbe.org/3hmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hmf RCSB], [https://www.ebi.ac.uk/pdbsum/3hmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hmf ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>  

[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Edwards A]]

[[Category: Filippakopoulos P]]

[[Category: Keates T]]

[[Category: Knapp S]]

[[Category: Muniz J]]

[[Category: Picaud S]]

[[Category: Weigelt J]]

[[Category: Von Delft F]]