3eiq: Difference between revisions

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 ==Crystal structure of Pdcd4-eIF4A==
-<StructureSection load='3eiq' size='340' side='right' caption='[[3eiq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
+<StructureSection load='3eiq' size='340' side='right'caption='[[3eiq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3eiq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EIQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3eiq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EIQ FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eiq OCA], [http://pdbe.org/3eiq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eiq RCSB], [http://www.ebi.ac.uk/pdbsum/3eiq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eiq ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eiq OCA], [https://pdbe.org/3eiq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eiq RCSB], [https://www.ebi.ac.uk/pdbsum/3eiq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eiq ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Note=Decreases benign tumor development and malignant progression.
 == Function ==
-[[http://www.uniprot.org/uniprot/IF4A1_HUMAN IF4A1_HUMAN]] ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.<ref>PMID:19153607</ref> <ref>PMID:19204291</ref>  [[http://www.uniprot.org/uniprot/PDCD4_MOUSE PDCD4_MOUSE]] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.<ref>PMID:12482958</ref> <ref>PMID:12894233</ref> <ref>PMID:16024603</ref> <ref>PMID:17060447</ref>
+[https://www.uniprot.org/uniprot/IF4A1_HUMAN IF4A1_HUMAN] ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.<ref>PMID:19153607</ref> <ref>PMID:19204291</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 ==See Also==
-*[[Cell death protein|Cell death protein]]
+*[[Cell death protein 3D structures|Cell death protein 3D structures]]
-*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
+*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: Cheng, Z]]
+[[Category: Mus musculus]]
-[[Category: Loh, P G]]
+[[Category: Cheng Z]]
-[[Category: Song, H]]
+[[Category: Loh PG]]
-[[Category: Anti-oncogene]]
+[[Category: Song H]]
-[[Category: Antitumor protein]]
-[[Category: Apoptosis]]
-[[Category: Atp-binding]]
-[[Category: Cell cycle]]
-[[Category: Helicase]]
-[[Category: Hydrolase]]
-[[Category: Hydrolase-antitumor protein complex]]
-[[Category: Initiation factor]]
-[[Category: Nucleotide-binding]]
-[[Category: Nucleus]]
-[[Category: Pdcd4]]
-[[Category: Phosphoprotein]]
-[[Category: Protein biosynthesis]]
-[[Category: Rna-binding]]
-[[Category: Translation]]