6m7x: Difference between revisions

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 ==Structure of human CYP11B1 in complex with fadrozole==
-<StructureSection load='6m7x' size='340' side='right' caption='[[6m7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='6m7x' size='340' side='right'caption='[[6m7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6m7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M7X FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6m7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M7X FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JD7:4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile'>JD7</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.095&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP11B1, S11BH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JD7:4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile'>JD7</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Steroid_11-beta-monooxygenase Steroid 11-beta-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.15.4 1.14.15.4] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7x OCA], [https://pdbe.org/6m7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m7x RCSB], [https://www.ebi.ac.uk/pdbsum/6m7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7x ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7x OCA], [http://pdbe.org/6m7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m7x RCSB], [http://www.ebi.ac.uk/pdbsum/6m7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7x ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/C11B1_HUMAN C11B1_HUMAN]] Familial hyperaldosteronism type I;Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2.
+[https://www.uniprot.org/uniprot/C11B1_HUMAN C11B1_HUMAN] Familial hyperaldosteronism type I;Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2.
 == Function ==
-[[http://www.uniprot.org/uniprot/C11B1_HUMAN C11B1_HUMAN]] Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
+[https://www.uniprot.org/uniprot/C11B1_HUMAN C11B1_HUMAN] Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 6m7x" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Steroid 11-beta-monooxygenase]]
+[[Category: Large Structures]]
-[[Category: Brixius-Anderko, S]]
+[[Category: Brixius-Anderko S]]
-[[Category: Scott, E E]]
+[[Category: Scott EE]]
-[[Category: Cortisol]]
-[[Category: Cyp11b1]]
-[[Category: Cytochrome p450]]
-[[Category: Oxidoreductase]]
-[[Category: S-fadrozole]]