5ung: Difference between revisions
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==XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)== | ==XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)== | ||
<StructureSection load='5ung' size='340' side='right' caption='[[5ung]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='5ung' size='340' side='right'caption='[[5ung]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ung]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5ung]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UNG FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8ES:N-BENZYL-N-(2-ETHYL-4-OXO-3-{[2-(2H-TETRAZOL-5-YL)[1,1-BIPHENYL]-4-YL]METHYL}-3,4-DIHYDROQUINAZOLIN-6-YL)THIOPHENE-2-CARBOXAMIDE'>8ES</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8ES:N-BENZYL-N-(2-ETHYL-4-OXO-3-{[2-(2H-TETRAZOL-5-YL)[1,1-BIPHENYL]-4-YL]METHYL}-3,4-DIHYDROQUINAZOLIN-6-YL)THIOPHENE-2-CARBOXAMIDE'>8ES</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ung FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ung OCA], [https://pdbe.org/5ung PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ung RCSB], [https://www.ebi.ac.uk/pdbsum/5ung PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ung ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/AGTR2_HUMAN AGTR2_HUMAN] X-linked non-syndromic intellectual disability. | |||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/AGTR2_HUMAN AGTR2_HUMAN] Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.<ref>PMID:15123706</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Babaoglu | [[Category: Homo sapiens]] | ||
[[Category: Batyuk | [[Category: Large Structures]] | ||
[[Category: Cherezov | [[Category: Babaoglu K]] | ||
[[Category: Garcia-Calvo | [[Category: Batyuk A]] | ||
[[Category: Han | [[Category: Cherezov V]] | ||
[[Category: Hollenstein | [[Category: Garcia-Calvo M]] | ||
[[Category: Hunter | [[Category: Han GW]] | ||
[[Category: Ishchenko | [[Category: Hollenstein K]] | ||
[[Category: Katritch | [[Category: Hunter MS]] | ||
[[Category: Katz | [[Category: Ishchenko A]] | ||
[[Category: Liu | [[Category: Katritch V]] | ||
[[Category: Moore | [[Category: Katz RD]] | ||
[[Category: Patel | [[Category: Liu W]] | ||
[[Category: Rudd | [[Category: Moore EL]] | ||
[[Category: Sadybekov | [[Category: Patel N]] | ||
[[Category: Sharma | [[Category: Rudd MT]] | ||
[[Category: Sheth | [[Category: Sadybekov A]] | ||
[[Category: Shipman | [[Category: Sharma S]] | ||
[[Category: Soisson | [[Category: Sheth P]] | ||
[[Category: Stevens | [[Category: Shipman JM]] | ||
[[Category: Tolstikova | [[Category: Soisson SM]] | ||
[[Category: Weierstall | [[Category: Stevens RC]] | ||
[[Category: White | [[Category: Tolstikova A]] | ||
[[Category: White | [[Category: Weierstall U]] | ||
[[Category: Zamlynny | [[Category: White KL]] | ||
[[Category: Zhang | [[Category: White TA]] | ||
[[Category: Zamlynny B]] | |||
[[Category: Zhang H]] | |||