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[[Image:2vi8.jpg|left|200px]]


{{Structure
==Crystal structure of S172AbsSHMT internal aldimine==
|PDB= 2vi8 |SIZE=350|CAPTION= <scene name='initialview01'>2vi8</scene>, resolution 1.67&Aring;
<StructureSection load='2vi8' size='340' side='right'caption='[[2vi8]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Plp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Mpd+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mpd+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=AC4:Po4+Binding+Site+For+Chain+A'>AC4</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[2vi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VI8 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vi8 OCA], [https://pdbe.org/2vi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vi8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vi8 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2vgu|2VGU]], [[1yjy|1YJY]], [[1yjs|1YJS]], [[1kl2|1KL2]], [[1kl1|1KL1]], [[1kkp|1KKP]], [[2vgs|2VGS]], [[1yjz|1YJZ]], [[2vgt|2VGT]], [[2vgv|2VGV]], [[1kkj|1KKJ]], [[2vgw|2VGW]], [[2vib|2VIB]], [[2via|2VIA]], [[2vi9|2VI9]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vi8 OCA], [http://www.ebi.ac.uk/pdbsum/2vi8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vi8 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2vi8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vi8 ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF S172ABSSHMT INTERNAL ALDIMINE'''
==See Also==
 
*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2VI8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI8 OCA].
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Glycine hydroxymethyltransferase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Appaji Rao N]]
[[Category: Bhavani, B S.]]
[[Category: Bhavani BS]]
[[Category: Murthy, M R.N.]]
[[Category: Murthy MRN]]
[[Category: Prakash, V.]]
[[Category: Prakash V]]
[[Category: Rajaram, V.]]
[[Category: Rajaram V]]
[[Category: Rao, N Appaji.]]
[[Category: Savithri HS]]
[[Category: Savithri, H S.]]
[[Category: e53q]]
[[Category: enzyme memory]]
[[Category: fthf]]
[[Category: one-carbon metabolism]]
[[Category: plp-dependent enzyme]]
[[Category: pyridoxal phosphate]]
[[Category: shmt]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:12:37 2008''

Latest revision as of 18:21, 13 December 2023

Crystal structure of S172AbsSHMT internal aldimineCrystal structure of S172AbsSHMT internal aldimine

Structural highlights

2vi8 is a 1 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.67Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q7SIB6_GEOSE Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2vi8, resolution 1.67Å

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