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==Structure of Pteridine Reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (Compound AX4)==
==Structure of Pteridine Reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (Compound AX4)==
<StructureSection load='3bmo' size='340' side='right' caption='[[3bmo]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3bmo' size='340' side='right'caption='[[3bmo]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3bmo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BMO FirstGlance]. <br>
<table><tr><td colspan='2'>[[3bmo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BMO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AX4:6-[(4-METHYLPHENYL)SULFANYL]PYRIMIDINE-2,4-DIAMINE'>AX4</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AX4:6-[(4-METHYLPHENYL)SULFANYL]PYRIMIDINE-2,4-DIAMINE'>AX4</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c7v|2c7v]], [[3bmd|3bmd]], [[3bme|3bme]], [[3bmf|3bmf]], [[3bmc|3bmc]], [[3bmg|3bmg]], [[3bmi|3bmi]], [[3bmj|3bmj]], [[3bmk|3bmk]], [[3bmh|3bmh]], [[3bmm|3bmm]], [[3bmn|3bmn]], [[3bml|3bml]], [[3bmq|3bmq]], [[3bmr|3bmr]], [[3bms|3bms]], [[3bmt|3bmt]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c7v|2c7v]], [[3bmd|3bmd]], [[3bme|3bme]], [[3bmf|3bmf]], [[3bmc|3bmc]], [[3bmg|3bmg]], [[3bmi|3bmi]], [[3bmj|3bmj]], [[3bmk|3bmk]], [[3bmh|3bmh]], [[3bmm|3bmm]], [[3bmn|3bmn]], [[3bml|3bml]], [[3bmq|3bmq]], [[3bmr|3bmr]], [[3bms|3bms]], [[3bmt|3bmt]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bmo OCA], [http://pdbe.org/3bmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bmo RCSB], [http://www.ebi.ac.uk/pdbsum/3bmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bmo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bmo OCA], [https://pdbe.org/3bmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bmo RCSB], [https://www.ebi.ac.uk/pdbsum/3bmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bmo ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Trybb]]
[[Category: Trybb]]
[[Category: Hunter, W N]]
[[Category: Hunter, W N]]

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