2uz9: Difference between revisions

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-[[Image:2uz9.jpg|left|200px]]
- {{Structure
+==Human guanine deaminase (guaD) in complex with zinc and its product Xanthine.==
-|PDB= 2uz9 |SIZE=350|CAPTION= <scene name='initialview01'>2uz9</scene>, resolution 2.30&Aring;
+<StructureSection load='2uz9' size='340' side='right'caption='[[2uz9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+1452'>AC1</scene> and <scene name='pdbsite=AC2:Xan+Binding+Site+For+Residue+A+1453'>AC2</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=XAN:XANTHINE'>XAN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+<table><tr><td colspan='2'>[[2uz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZ9 FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanine_deaminase Guanine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.3 3.5.4.3] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XAN:XANTHINE'>XAN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz9 OCA], [https://pdbe.org/2uz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2uz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz9 ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz9 OCA], [http://www.ebi.ac.uk/pdbsum/2uz9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2uz9 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/GUAD_HUMAN GUAD_HUMAN] Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uz9 ConSurf].
+<div style="clear:both"></div>
-'''HUMAN GUANINE DEAMINASE (GUAD) IN COMPLEX WITH ZINC AND ITS PRODUCT XANTHINE.'''
+==See Also==
+*[[Deaminase 3D structures|Deaminase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-UZ9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ9 OCA].
-[[Category: Guanine deaminase]]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Berglund, H.]]
+[[Category: Berglund H]]
-[[Category: Busam, R.]]
+[[Category: Busam R]]
-[[Category: Collins, R.]]
+[[Category: Collins R]]
-[[Category: Dahlgren, L G.]]
+[[Category: Dahlgren LG]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Flodin, S.]]
+[[Category: Flodin S]]
-[[Category: Flores, A.]]
+[[Category: Flores A]]
-[[Category: Graslund, S.]]
+[[Category: Graslund S]]
-[[Category: Hallberg, B M.]]
+[[Category: Hallberg BM]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hammarstrom M]]
-[[Category: Holmberg-Schiavone, L.]]
+[[Category: Holmberg-Schiavone L]]
-[[Category: Johansson, I.]]
+[[Category: Johansson I]]
-[[Category: Kallas, A.]]
+[[Category: Kallas A]]
-[[Category: Karlberg, T.]]
+[[Category: Karlberg T]]
-[[Category: Kotenyova, T.]]
+[[Category: Kotenyova T]]
-[[Category: Lehtio, L.]]
+[[Category: Lehtio L]]
-[[Category: Moche, M.]]
+[[Category: Moche M]]
-[[Category: Nordlund, P.]]
+[[Category: Nordlund P]]
-[[Category: Nyman, T.]]
+[[Category: Nyman T]]
-[[Category: Ogg, D.]]
+[[Category: Ogg D]]
-[[Category: Persson, C.]]
+[[Category: Persson C]]
-[[Category: Sagemark, J.]]
+[[Category: Sagemark J]]
-[[Category: Sgc, Structural Genomics Consortium.]]
+[[Category: Stenmark P]]
-[[Category: Stenmark, P.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Thorsell AG]]
-[[Category: Thorsell, A G.]]
+[[Category: Weigelt J]]
-[[Category: Van-Den-Berg, S.]]
+[[Category: Welin M]]
-[[Category: Weigelt, J.]]
+[[Category: Van den berg S]]
-[[Category: Welin, M.]]
-[[Category: guanine aminohydrolase]]
-[[Category: hydrolase]]
-[[Category: purine metabolism]]
-[[Category: zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:30 2008''