Ragulator complex: Difference between revisions

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<StructureSection load='5y39' size='340' side='right' caption='Human ragulator complex proteins: LAMTOR1 coiled coil domain (grey) + LAMTOR2 roadblock domain (green) + LAMTOR3 roadblock domain (pink) + LAMTOR4 roadblock domain (yellow) + LAMTOR5 roadblock domain (magenta) PDB code [[5y39]]' scene=''>
<StructureSection load='5y39' size='340' side='right' caption='Human ragulator complex proteins: LAMTOR1 coiled coil domain (grey and cyan) + LAMTOR2 roadblock domain (green and red) + LAMTOR3 roadblock domain (pink and gold) + LAMTOR4 roadblock domain (yellow and wheat) + LAMTOR5 roadblock domain (magenta and blue) PDB code [[5y39]]' scene=''>


The '''ragulator complex''' (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it<ref>PMID:29285400</ref>.
The '''ragulator complex''' (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it<ref>PMID:29285400</ref>.


== Function ==
== Disease ==
== Relevance ==
== Structural highlights ==
</StructureSection>
==3D structures of ragulator complex==
==3D structures of ragulator complex==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[Ragulator complex 3D structures]]
 
[[6b9x]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + hepatitis B virus interacting protein  - human<br />
[[5y39]], [[5y3a]], [[6ehp]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  <br />
[[5x6u]] - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  <br />
[[6ehr]] - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + Ras-related GTP-binding proteins A, C <br />
[[5x6v]] - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5  + Ras-related GTP-binding proteins A, C <br />
[[5vok]], [[5y38]] - hLAMTOR4 + LAMTOR5<br />


== References ==
== References ==
<references/>
<references/>
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 10:38, 8 October 2023


The ragulator complex (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it[1].

3D structures of ragulator complex

Ragulator complex 3D structures

References

  1. ↑ Mu Z, Wang L, Deng W, Wang J, Wu G. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane. Cell Discov. 2017 Dec 26;3:17049. doi: 10.1038/celldisc.2017.49. eCollection, 2017. PMID:29285400 doi:http://dx.doi.org/10.1038/celldisc.2017.49

Human ragulator complex proteins: LAMTOR1 coiled coil domain (grey and cyan) + LAMTOR2 roadblock domain (green and red) + LAMTOR3 roadblock domain (pink and gold) + LAMTOR4 roadblock domain (yellow and wheat) + LAMTOR5 roadblock domain (magenta and blue) PDB code 5y39

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Michal Harel, Wayne Decatur
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