2rd4: Difference between revisions

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-[[Image:2rd4.jpg|left|200px]]
- {{Structure
+==Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution==
-|PDB= 2rd4 |SIZE=350|CAPTION= <scene name='initialview01'>2rd4</scene>, resolution 2.97&Aring;
+<StructureSection load='2rd4' size='340' side='right'caption='[[2rd4]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+<table><tr><td colspan='2'>[[2rd4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RD4 FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rd4 OCA], [https://pdbe.org/2rd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rd4 RCSB], [https://www.ebi.ac.uk/pdbsum/2rd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rd4 ProSAT]</span></td></tr>
-|RELATEDENTRY=[[1s6b|1S6B]]
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rd4 OCA], [http://www.ebi.ac.uk/pdbsum/2rd4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rd4 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/PA2B1_NAJSG PA2B1_NAJSG] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rd4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rd4 ConSurf].
+<div style="clear:both"></div>
-'''Design of specific inhibitors of Phospholipase A2: Crystal structure of the complex of phospholipase A2 with pentapeptide Leu-Val-Phe-Phe-Ala at 2.9 A resolution'''
+==See Also==
+*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-RD4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RD4 OCA].
+[[Category: Large Structures]]
 [[Category: Naja sagittifera]]
-[[Category: Phospholipase A(2)]]
+[[Category: Kaur A]]
-[[Category: Protein complex]]
+[[Category: Kaur P]]
-[[Category: Kaur, A.]]
+[[Category: Mirza Z]]
-[[Category: Kaur, P.]]
+[[Category: Sharma S]]
-[[Category: Mirza, Z.]]
+[[Category: Singh N]]
-[[Category: Sharma, S.]]
+[[Category: Singh TP]]
-[[Category: Singh, N.]]
+[[Category: Sinha M]]
-[[Category: Singh, T P.]]
+[[Category: Srinivasan A]]
-[[Category: Sinha, M.]]
-[[Category: Srinivasan, A.]]
-[[Category: calcium]]
-[[Category: complex]]
-[[Category: hydrolase]]
-[[Category: lipid degradation]]
-[[Category: metal-binding]]
-[[Category: peptide inhibitor]]
-[[Category: phospholipase a2]]
-[[Category: secreted]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:04 2008''