6h0b: Difference between revisions

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 ==Crystal structure of the human GalNAc-T4 in complex with UDP, manganese and the diglycopeptide 6.==
-<StructureSection load='6h0b' size='340' side='right' caption='[[6h0b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='6h0b' size='340' side='right'caption='[[6h0b]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6h0b]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H0B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6h0b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6H0B FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polypeptide_N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.41 2.4.1.41] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0b OCA], [http://pdbe.org/6h0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h0b RCSB], [http://www.ebi.ac.uk/pdbsum/6h0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0b ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6h0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0b OCA], [https://pdbe.org/6h0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6h0b RCSB], [https://www.ebi.ac.uk/pdbsum/6h0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0b ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GALT4_HUMAN GALT4_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
+[https://www.uniprot.org/uniprot/GALT4_HUMAN GALT4_HUMAN] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Polypeptide N-acetylgalactosaminyltransferase]]
+[[Category: Homo sapiens]]
-[[Category: Clausen, H]]
+[[Category: Large Structures]]
-[[Category: Coelho, H]]
+[[Category: Clausen H]]
-[[Category: Companon, I]]
+[[Category: Coelho H]]
-[[Category: Corzana, F]]
+[[Category: Companon I]]
-[[Category: Daniel, E J.P]]
+[[Category: Corzana F]]
-[[Category: Diniz, A]]
+[[Category: Daniel EJP]]
-[[Category: Gerken, T A]]
+[[Category: Diniz A]]
-[[Category: Hurtado-Guerrero, R]]
+[[Category: Gerken TA]]
-[[Category: Jimenez-Barbero, J]]
+[[Category: Hurtado-Guerrero R]]
-[[Category: Lagartera, L]]
+[[Category: Jimenez-Barbero J]]
-[[Category: Lira-Navarrete, E]]
+[[Category: Lagartera L]]
-[[Category: Marcelo, F]]
+[[Category: Lira-Navarrete E]]
-[[Category: Raich, L]]
+[[Category: Marcelo F]]
-[[Category: Rivas, M de las]]
+[[Category: Raich L]]
-[[Category: Rovira, C]]
+[[Category: Rovira C]]
-[[Category: Enzyme kinetic]]
+[[Category: De las Rivas M]]
-[[Category: Galnac-t]]
-[[Category: Galnac-t4]]
-[[Category: Long-range glycosylation preference]]
-[[Category: Molecular dynamic]]
-[[Category: Short-range glycosylation preference]]
-[[Category: Std-nmr]]
-[[Category: Transferase]]