2wwh: Difference between revisions
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==Plasmodium falciparum thymidylate kinase in complex with AP5dT== | ==Plasmodium falciparum thymidylate kinase in complex with AP5dT== | ||
<StructureSection load='2wwh' size='340' side='right' caption='[[2wwh]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='2wwh' size='340' side='right'caption='[[2wwh]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wwh]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wwh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWH FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=T5A:P1-(5-ADENOSYL)P5-(5-THYMIDYL)PENTAPHOSPHATE'>T5A</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwh OCA], [https://pdbe.org/2wwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wwh RCSB], [https://www.ebi.ac.uk/pdbsum/2wwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wwh ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KTHY_PLAF7 KTHY_PLAF7] Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP (PubMed:18477629, PubMed:19126267, PubMed:31934749, PubMed:20353400). Can also phosphorylate dGMP and to a lesser extent GMP, dUMP and dIMP (PubMed:18477629, PubMed:19126267, PubMed:31934749, PubMed:20353400). Can use either ATP or dATP as phosphate donors in presence of Mg(2+) (PubMed:18477629).<ref>PMID:18477629</ref> <ref>PMID:19126267</ref> <ref>PMID:20353400</ref> <ref>PMID:31934749</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Plasmodium falciparum 3D7]] | ||
[[Category: Brannigan | [[Category: Brannigan JA]] | ||
[[Category: Carrero-Lerida | [[Category: Carrero-Lerida J]] | ||
[[Category: Fogg | [[Category: Fogg MJ]] | ||
[[Category: Gilbert | [[Category: Gilbert IH]] | ||
[[Category: Gonzalez-Pacanowska | [[Category: Gonzalez-Pacanowska D]] | ||
[[Category: Ruiz-Perez | [[Category: Ruiz-Perez LM]] | ||
[[Category: Silva | [[Category: Silva APG]] | ||
[[Category: Whittingham | [[Category: Whittingham JL]] | ||
[[Category: Wilkinson | [[Category: Wilkinson AJ]] | ||
[[Category: Wilson | [[Category: Wilson KS]] | ||