6mjw: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 6mjw is ON HOLD
+==human cGAS catalytic domain bound with the inhibitor G150==
+<StructureSection load='6mjw' size='340' side='right'caption='[[6mjw]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6mjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.405&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JUJ:1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjw OCA], [https://pdbe.org/6mjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mjw RCSB], [https://www.ebi.ac.uk/pdbsum/6mjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
-Authors:
+==See Also==
+*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
-Description:
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Adura C]]
+[[Category: Aida J]]
+[[Category: Asano Y]]
+[[Category: Gao P]]
+[[Category: Glickman JF]]
+[[Category: Gogakos T]]
+[[Category: Hashizume S]]
+[[Category: Imaeda T]]
+[[Category: Jennings AJ]]
+[[Category: Kamei T]]
+[[Category: Kuroita T]]
+[[Category: Kuryavyi V]]
+[[Category: Lama L]]
+[[Category: Meinke P]]
+[[Category: Michinom M]]
+[[Category: Miller M]]
+[[Category: Okamoto R]]
+[[Category: Patel DJ]]
+[[Category: Ramos-Espiritu L]]
+[[Category: Stamford A]]
+[[Category: Steinberg JI]]
+[[Category: Tomita D]]
+[[Category: Tuschl T]]
+[[Category: Xie W]]