6hr8: Difference between revisions

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-'''Unreleased structure'''
-The entry 6hr8 is ON HOLD
+==HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution==
+<StructureSection load='6hr8' size='340' side='right'caption='[[6hr8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hr8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus_DSM_2095 Methanothermococcus thermolithotrophicus DSM 2095]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HR8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hr8 OCA], [https://pdbe.org/6hr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hr8 RCSB], [https://www.ebi.ac.uk/pdbsum/6hr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hr8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A4V8GZY0_METTL A0A4V8GZY0_METTL]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyses the last step in mevalonate biosynthesis. HMGR is the target of statin inhibitors that regulate cholesterol concentration in human blood. Here, we report the properties and structures of HMGR from the archaeon Methanothermococcus thermolithotrophicus (mHMGR). The structures of the apoenzyme and the NADPH-complex are highly similar to those of human HMGR. A notable exception is C-terminal helix (Lalpha10-11) that is straight in both mHMGR structures. This helix is kinked and closes the active site in the human enzyme ternary complex, pointing to a substrate-induced structural rearrangement of C-terminal in class-I HMGRs during the catalytic cycle. This article is protected by copyright. All rights reserved.
-Authors: Wagner, T., Voegeli, B., Erb, T.J., Shima, S.
+Crystal structure of archaeal HMG-CoA reductase: insights into structural changes of the C-terminal helix of the class-I enzyme.,Vogeli B, Shima S, Erb T, Wagner T FEBS Lett. 2019 Jan 31. doi: 10.1002/1873-3468.13331. PMID:30702149<ref>PMID:30702149</ref>
-Description: HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Shima, S]]
+<div class="pdbe-citations 6hr8" style="background-color:#fffaf0;"></div>
-[[Category: Wagner, T]]
-[[Category: Voegeli, B]]
+==See Also==
-[[Category: Erb, T.J]]
+*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Methanothermococcus thermolithotrophicus DSM 2095]]
+[[Category: Erb TJ]]
+[[Category: Shima S]]
+[[Category: Voegeli B]]
+[[Category: Wagner T]]