2wpb: Difference between revisions
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==Crystal structure of the E192N mutant of E. Coli N-acetylneuraminic acid lyase in complex with pyruvate and the inhibitor (2R,3R)-2,3,4- trihydroxy-N,N-dipropylbutanamide in space group P21 crystal form I== | ==Crystal structure of the E192N mutant of E. Coli N-acetylneuraminic acid lyase in complex with pyruvate and the inhibitor (2R,3R)-2,3,4- trihydroxy-N,N-dipropylbutanamide in space group P21 crystal form I== | ||
<StructureSection load='2wpb' size='340' side='right' caption='[[2wpb]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='2wpb' size='340' side='right'caption='[[2wpb]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wpb]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wpb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WPB FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene>, <scene name='pdbligand=ZZI:(2R,3R)-2,3,4-TRIHYDROXY-N,N-DIPROPYLBUTANAMIDE'>ZZI</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wpb OCA], [https://pdbe.org/2wpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wpb RCSB], [https://www.ebi.ac.uk/pdbsum/2wpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wpb ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[ | *[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Berry | [[Category: Berry A]] | ||
[[Category: Bolt | [[Category: Bolt AH]] | ||
[[Category: Campeotto | [[Category: Campeotto I]] | ||
[[Category: Dennis | [[Category: Dennis CA]] | ||
[[Category: Harman | [[Category: Harman TA]] | ||
[[Category: Nelson | [[Category: Nelson A]] | ||
[[Category: Pearson | [[Category: Pearson AR]] | ||
[[Category: Phillips | [[Category: Phillips SEV]] | ||
[[Category: Trinh | [[Category: Trinh CH]] | ||