2wbp: Difference between revisions

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 ==Crystal structure of VioC in complex with Fe(II), (2S,3S)- hydroxyarginine, and succinate==
-<StructureSection load='2wbp' size='340' side='right' caption='[[2wbp]], [[Resolution|resolution]] 1.16&Aring;' scene=''>
+<StructureSection load='2wbp' size='340' side='right'caption='[[2wbp]], [[Resolution|resolution]] 1.16&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wbp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1305 As 4.1305]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WBP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wbp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_vinaceus Streptomyces vinaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WBP FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=ZZU:(2S,3S)-3-HYDROXYARGININE'>ZZU</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.16&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wbo|2wbo]], [[2wbq|2wbq]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=ZZU:(2S,3S)-3-HYDROXYARGININE'>ZZU</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbp OCA], [http://pdbe.org/2wbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wbp RCSB], [http://www.ebi.ac.uk/pdbsum/2wbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbp ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wbp OCA], [https://pdbe.org/2wbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wbp RCSB], [https://www.ebi.ac.uk/pdbsum/2wbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wbp ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ARGHX_STRVI ARGHX_STRVI] Involved in the biosynthesis of capreomycidine, an unusual amino acid used by non-ribosomal peptide synthases (NRPS) to make the tuberactinomycin class of peptide antibiotics such as viomycin and capreomycin. Catalyzes the stereospecific hydroxylation of the C3 of (2S)-arginine to generate (3S)-hydroxy-(2S)-arginine. Usually clavaminic acid synthase-like oxygenases catalyze the formation of threo diastereomers, however VioC produces the erythro diastereomer of beta-carbon-hydroxylated L-arginine. It exerts a broad substrate specificity by accepting the analogs L-homoarginine and L-canavanine for the beta-carbon hydroxylation.<ref>PMID:15368580</ref> <ref>PMID:15368582</ref> <ref>PMID:19490124</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 29: @@
 </div>
 <div class="pdbe-citations 2wbp" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: As 4 1305]]
+[[Category: Large Structures]]
-[[Category: Essen, L O]]
+[[Category: Streptomyces vinaceus]]
-[[Category: Helmetag, V]]
+[[Category: Essen L-O]]
-[[Category: Marahiel, M A]]
+[[Category: Helmetag V]]
-[[Category: Samel, S A]]
+[[Category: Marahiel MA]]
-[[Category: Thomas, M G]]
+[[Category: Samel SA]]
-[[Category: Alpha-ketoglutarate]]
+[[Category: Thomas MG]]
-[[Category: Cbeta-hydroxylation]]
-[[Category: Nrp]]
-[[Category: Oxidoreductase]]
-[[Category: Viomycin]]