2w3w: Difference between revisions

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 ==MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR M. AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)==
-<StructureSection load='2w3w' size='340' side='right' caption='[[2w3w]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+<StructureSection load='2w3w' size='340' side='right'caption='[[2w3w]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w3w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis_gallinarum"_sternberg_1892 "bacillus tuberculosis gallinarum" sternberg 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3W FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w3w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_avium Mycobacterium avium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3W FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w3v|2w3v]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3w OCA], [https://pdbe.org/2w3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3w RCSB], [https://www.ebi.ac.uk/pdbsum/2w3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3w ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3w OCA], [http://pdbe.org/2w3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3w RCSB], [http://www.ebi.ac.uk/pdbsum/2w3w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3w ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/O30463_MYCAV O30463_MYCAV]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
+[https://www.uniprot.org/uniprot/O30463_MYCAV O30463_MYCAV] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 23: / Line 22: @@
 ==See Also==
-*[[Dihydrofolate reductase|Dihydrofolate reductase]]
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 __TOC__
 </StructureSection>
-[[Category: Bacillus tuberculosis gallinarum sternberg 1892]]
+[[Category: Large Structures]]
-[[Category: Dihydrofolate reductase]]
+[[Category: Mycobacterium avium]]
-[[Category: Borhani, D W]]
+[[Category: Borhani DW]]
-[[Category: Leung, A K.W]]
+[[Category: Leung AKW]]
-[[Category: Reynolds, R C]]
+[[Category: Reynolds RC]]
-[[Category: Lipophilic antifolate]]
-[[Category: Nadp]]
-[[Category: Nonclassical antifolate]]
-[[Category: One-carbon metabolism]]
-[[Category: Oxidoreductase]]
-[[Category: Reductase]]