SAM decarboxylase: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

@@ Line 7: / Line 7: @@
 ==Structural insight ==
-The biological assembly of S-adenosylmethionine decarboxylase is <scene name='49/493297/Cv/2'>tetramer</scene>, containing 2 α and 2 β chains. <scene name='49/493297/Cv/4'>AMD active site contains residues from all protomers</scene>.  The cleavage of the precursor molecule occurs at residue <scene name='49/493297/Cv/5'>serine 63 which becomes a pyruvolyl group</scene><ref>PMID:20124698</ref>. Water molecules shown as red spheres.
+The biological assembly of S-adenosylmethionine decarboxylase is <scene name='49/493297/Cv/6'>tetramer</scene>, containing 2 α and 2 β chains. <scene name='49/493297/Cv/7'>AMD active site contains residues from all protomers</scene>. The cleavage of the precursor molecule occurs at residue <scene name='49/493297/Cv/8'>serine 63 which becomes a pyruvolyl group</scene><ref>PMID:20124698</ref>. Water molecules are shown as red spheres.
 </StructureSection>
 ==3D structures of S-adenosylmethionine decarboxylase==
@@ Line 14: / Line 14: @@
 {{#tree:id=OrganizedByTopic|openlevels=0|
-*S-adenosylmethionine decarboxylase
+*S-adenosylmethionine decarboxylase binary complexes
-**[[3iwb]] - TmAMD (mutant) + pyruvate - ''Thermotoga maritima''<br />
 **[[1jen]], [[3ep9]] – hAMD + pyruvate – human<br />
 **[[3ep3]], [[3ep4]], [[3ep5]] - hAMD (mutant) + pyruvate<br />
-**[[1mhm]] - AMD + pyruvate – potato
+**[[1jl0]] - hAMD (mutant) + putrescine <br />
+**[[1mhm]] - AMD + pyruvate – potato<br />
+**[[3iwb]] - TmAMD (mutant) + pyruvate - ''Thermotoga maritima''<br />
-*S-adenosylmethionine decarboxylase binary complex
+*S-adenosylmethionine decarboxylase ternary complex
-**[[1jl0]] - hAMD (mutant) + putrescine <br />
+**[[3ep6]], [[3ep7]], [[3ep8]] - hAMD (mutant) + AdoMet + pyruvate<br />
+**[[3epa]], [[3epb]] - hAMD (mutant) + putrescine + pyruvate<br />
 **[[3iwc]] - TmAMD + AdoMet + pyruvate<br />
 **[[3iwd]] - TmAMD + adenosine derivative + pyruvate<br />
-**[[3ep6]], [[3ep7]], [[3ep8]] - hAMD (mutant) + AdoMet + pyruvate<br />
-**[[3epa]], [[3epb]] - hAMD (mutant) + putrescine + pyruvate<br />
-*S-adenosylmethionine decarboxylase ternary complex
+*S-adenosylmethionine decarboxylase quaternary complex
 **[[1i72]], [[1i79]], [[3dz2]], [[3dz4]], [[3dz5]], [[3dz6]], [[3dz7]], [[3h0v]], [[3h0w]] - hAMD + adenosine derivative + putrescine + pyruvate<br />
@@ Line 39: / Line 39: @@
 *S-adenosylmethionine decarboxylase precursor
-**[[1tlu]], [[1vr7]] - TmAMD <br />
+**[[1msv]] - hAMDP (mutant) + putrescine<br />
-**[[1tmi]] - TmAMD (mutant)<br />
+**[[1tlu]], [[1vr7]] - TmAMDP <br />
-**[[2iii]] – AMD – ''Aquifex aeolicus''<br />
+**[[1tmi]] - TmAMDP (mutant)<br />
-**[[1msv]] - hAMD (mutant) + putrescine<br />
+**[[2iii]] – AMDP – ''Aquifex aeolicus''<br />
-**[[5tvo]] - TbAMD + pyruvate<br />
+**[[5tvo]] - TbAMDP + pyruvate<br />
 }}
 == References ==
 <references/>
 [[Category:Topic Page]]