2v54: Difference between revisions
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==Crystal structure of vaccinia virus thymidylate kinase bound to TDP== | ==Crystal structure of vaccinia virus thymidylate kinase bound to TDP== | ||
<StructureSection load='2v54' size='340' side='right' caption='[[2v54]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='2v54' size='340' side='right'caption='[[2v54]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v54]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2v54]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Copenhagen Vaccinia virus Copenhagen]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V54 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=TYD:THYMIDINE-5-DIPHOSPHATE'>TYD</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v54 OCA], [https://pdbe.org/2v54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v54 RCSB], [https://www.ebi.ac.uk/pdbsum/2v54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v54 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KTHY_VACCC KTHY_VACCC] Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Thymidylate kinase|Thymidylate kinase]] | *[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Vaccinia virus Copenhagen]] | ||
[[Category: Agrofoglio | [[Category: Agrofoglio LA]] | ||
[[Category: Balzarini | [[Category: Balzarini J]] | ||
[[Category: Caillat | [[Category: Caillat C]] | ||
[[Category: Deville-Bonne | [[Category: Deville-Bonne D]] | ||
[[Category: Meyer | [[Category: Meyer P]] | ||
[[Category: Pochet | [[Category: Pochet S]] | ||
[[Category: Topalis | [[Category: Topalis D]] | ||