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==Crystal structure of 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis==
==Crystal structure of 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis==
<StructureSection load='2qkf' size='340' side='right' caption='[[2qkf]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='2qkf' size='340' side='right'caption='[[2qkf]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2qkf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QKF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2qkf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_B Neisseria meningitidis serogroup B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QKF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kdsA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 Neisseria meningitidis serogroup B])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkf OCA], [https://pdbe.org/2qkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qkf RCSB], [https://www.ebi.ac.uk/pdbsum/2qkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qkf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qkf OCA], [http://pdbe.org/2qkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qkf RCSB], [http://www.ebi.ac.uk/pdbsum/2qkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qkf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDSA_NEIMB KDSA_NEIMB]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qkf ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qkf ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The analysis of the interaction of threose 4-phosphate and 2-deoxyerythrose 4-phosphate with 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS) reveals previously unrecognised mechanistic differences between the DAH7PS-catalysed reaction and that catalysed by the closely related enzyme, 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS).
Mechanistic divergence of two closely related aldol-like enzyme-catalysed reactions.,Ahn M, Pietersma AL, Schofield LR, Parker EJ Org Biomol Chem. 2005 Nov 21;3(22):4046-9. Epub 2005 Oct 6. PMID:16267580<ref>PMID:16267580</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2qkf" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Kdo-8-phosphate synthase|Kdo-8-phosphate synthase]]
*[[Kdo-8-phosphate synthase|Kdo-8-phosphate synthase]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 3-deoxy-8-phosphooctulonate synthase]]
[[Category: Large Structures]]
[[Category: Neisseria meningitidis serogroup b]]
[[Category: Neisseria meningitidis serogroup B]]
[[Category: Cochrane, F C]]
[[Category: Cochrane FC]]
[[Category: Jameson, G B]]
[[Category: Jameson GB]]
[[Category: Parker, E J]]
[[Category: Parker EJ]]
[[Category: Patchett, M L]]
[[Category: Patchett ML]]
[[Category: Kdo8 kdop]]
[[Category: Kdo8p]]
[[Category: Kdop]]
[[Category: Lipopolysaccharide]]
[[Category: Lipopolysaccharide biosynthesis]]
[[Category: Lyase]]
[[Category: Manno-octulosonate]]
[[Category: Synthase]]
[[Category: Tim barrel]]
[[Category: Transferase]]

Latest revision as of 14:34, 30 August 2023

Crystal structure of 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidisCrystal structure of 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis

Structural highlights

2qkf is a 4 chain structure with sequence from Neisseria meningitidis serogroup B. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KDSA_NEIMB

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2qkf, resolution 1.75Å

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OCA
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