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==Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine==
==Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine==
<StructureSection load='2qb4' size='340' side='right' caption='[[2qb4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2qb4' size='340' side='right'caption='[[2qb4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2qb4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QB4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2qb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QB4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DSM:3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE'>DSM</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a65|2a65]], [[2q6h|2q6h]], [[2q72|2q72]], [[2qei|2qei]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DSM:3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE'>DSM</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">snf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qb4 OCA], [https://pdbe.org/2qb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qb4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qb4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qb4 OCA], [http://pdbe.org/2qb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qb4 RCSB], [http://www.ebi.ac.uk/pdbsum/2qb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qb4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O67854_AQUAE O67854_AQUAE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Leucine transporter|Leucine transporter]]
*[[Leucine transporter|Leucine transporter]]
*[[Symporter 3D structures|Symporter 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aquae]]
[[Category: Aquifex aeolicus VF5]]
[[Category: Gouaux, E]]
[[Category: Large Structures]]
[[Category: Singh, S K]]
[[Category: Gouaux E]]
[[Category: Yamashita, A]]
[[Category: Singh SK]]
[[Category: Dibenzazepine]]
[[Category: Yamashita A]]
[[Category: Membrane protein]]
[[Category: Neurotransmitter sodium symporter]]
[[Category: Occluded]]
[[Category: Secondary amine tricyclic antidepressant]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Transport protein]]

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