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| There is a Zn-binding motif on p53. The p53 Zn atom is coordinated by residues <scene name='26/26327/B_chain_and_dna/12'>C176, H179, C238, and C242</scene> that are located on two loops, respectively. It is conceivable that the zinc plays a role in stabilizing the two loops through | | There is a Zn-binding motif on p53. The p53 Zn atom is coordinated by residues <scene name='26/26327/B_chain_and_dna/12'>C176, H179, C238, and C242</scene> that are located on two loops, respectively. It is conceivable that the zinc plays a role in stabilizing the two loops through |
| coordination. The Zn has been represented as a magenta sphere, and R248 in space filling, in the scene at the right. | | coordination. The Zn has been represented as a magenta sphere, and R248 in space filling, in the scene at the right. |
| </StructureSection>
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| ==3D structures of p53 (Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}) == | | ==3D structures of p53== |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| | [[P53 3D structures]] |
| * p53 DNA-binding domain (residues 94-292)
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| ** [[2xwr]], [[2ocj]], [[2ybg]] – h-p53 DBD – human<BR />
| | </StructureSection> |
| ** [[2fej]] - h-p53 DBD - NMR<BR />
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| ** [[2wgx]], [[3d05]], [[3d06]], [[3d07]], [[3d08]], [[3d09]], [[2pcx]], [[2j1w]], [[2j1x]], [[2j1y]], [[2j1z]], [[2j20]], [[2j21]], [[2bim]], [[2bin]], [[2bio]], [[2bip]], [[2biq]], [[1uol]], [[4kvp]], [[4lo9]], [[4loe]], [[4lof]], [[4ibq]], [[4ibs]], [[4ibt]], [[4iby]], [[4ibz]], [[4ijt]], [[4mzi]], [[5lap]], [[6ff9]] - h-p53 DBD (mutant) <BR />
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| ** [[2ioi]], [[2ioo]], [[1hu8]] – m-p53 DBD – mouse<BR />
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| ** [[1t4w]] – p53-like DBD – ''Caenoharbditis elegans''
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| * p53 DNA-binding domain complex with DNA
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| ** [[3igk]], [[3igl]], [[3kz8]], [[3kmd]], [[2ac0]], [[2ady]], [[2ahi]], [[2ata]], [[1tsr]], [[1tup]], [[4hje]], [[5bua]], [[6fj5]], [[5mg7]], [[5mf7]], [[5mcw]], [[5mcu]], [[5mct]], [[5lgy]] – h-p53 DBD + DNA<BR />
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| ** [[3d0a]], [[3ts8]], [[4ibu]], [[4ibv]], [[4ibw]] - h-p53 DBD (mutant) + DNA<BR />
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| ** [[3q05]], [[3q06]] - h-p53 DBD + TD + DNA<br />
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| ** [[3exj]], [[3exl]], [[2p52]], [[2geq]] – m-p53 DBD + DNA
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| * p53 DNA-binding domain complex with small molecule
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| ** [[2x0u]], [[2x0v]], [[2x0w]], [[4agl]], [[4agm]], [[4agn]], [[4ago]], [[4agp]], [[4agq]], [[5aol]], [[5aoj]] – h-p53 DBD (mutant) + benzene derivative<BR />
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| ** [[3zme]] - h-p53 DBD (mutant) + pyrazol derivative<br />
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| **[[5aoi]], [[5ab9]] - h-p53 DBD (mutant) + indole derivative<br />
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| ** [[2vuk]] - h-p53 DBD + drug<BR />
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| **[[5g4o]], [[5g4n]], [[5g4m]], [[5aom]], [[5aok]], [[5aba]], [[5a7b]], [[5o1i]], [[5o1h]], [[5o1g]], [[5o1f]], [[5o1e]], [[5o1a]], [[5o1b]], [[5o1c]], [[5o1d]] - h-p53 DBD (mutant) + drug<br />
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| ** [[2iom]] - m-p53 DBD + propanol
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| * p53 DNA-binding domain complex with protein<br />
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| ** [[2k8f]] – h-p53 residues 1-39 + histone acetyltransferase (mutant) – NMR<BR />
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| ** [[2h1l]] - h-p53 DBD + large T antigen<BR />
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| ** [[1ycs]] - h-p53 DBD + 53BP2<BR />
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| ** [[1gzh]], [[1kzy]] - h-p53 DBD + tumor suppressor p53-binding protein<br />
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| **[[4xr8]] - h-p53 DBD + E6 + E6AP<br />
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| **[[4qo1]] - h-p53 DBD + nanobody<br />
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| * p53 transactivation domain (residues 15-29)
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| ** [[2z5s]], [[2z5t]] - h-p53 TAD + MDM4 protein<br />
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| ** [[1ycq]], [[1ycr]] - h-p53 TAD + MDM2 protein<br />
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| ** [[2l14]] – h-p53 TAD + CREB-binding protein<br />
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| ** [[2gs0]] – h-p53 TAD + RNA polymerase II transcription factor
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| * p53 tetramerization domain (residues 326-356)
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| ** [[2j0z]], [[3sak]], [[1sae]], [[1saf]], [[1sak]], [[1sal]], [[1olh]], [[1pes]], [[1pet]], [[1olg]], [[1hs5]]– h-p53 TD – NMR<BR />
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| ** [[1c26]], [[1aie]] - h-p53 TD<BR />
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| ** [[2j10]], [[2j11]], [[1a1u]] - h-p53 TD (mutant) – NMR<BR />
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| * p53 tetramerization+DBD domains
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| ** [[4mzr]], [[3q01]] – h-p53 + DNA<br />
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| }}
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| ==Additional Resources== | | ==Additional Resources== |