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==Crystal structure of PurO/IMP from Methanothermobacter thermoautotrophicus==
==Crystal structure of PurO/IMP from Methanothermobacter thermoautotrophicus==
<StructureSection load='2ntk' size='340' side='right' caption='[[2ntk]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='2ntk' size='340' side='right'caption='[[2ntk]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ntk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"methanobacterium_thermoautotrophicus"_(sic)_zeikus_and_wolfe_1972 "methanobacterium thermoautotrophicus" (sic) zeikus and wolfe 1972]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NTK FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ntk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ntl|2ntl]], [[2ntm|2ntm]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PurO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 "Methanobacterium thermoautotrophicus" (sic) Zeikus and Wolfe 1972])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntk OCA], [https://pdbe.org/2ntk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntk RCSB], [https://www.ebi.ac.uk/pdbsum/2ntk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntk ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_cyclohydrolase IMP cyclohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.10 3.5.4.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ntk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntk OCA], [http://pdbe.org/2ntk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ntk RCSB], [http://www.ebi.ac.uk/pdbsum/2ntk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PURO_METTH PURO_METTH]] Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP (By similarity).  
[https://www.uniprot.org/uniprot/PURO_METTH PURO_METTH] Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Cyclohydrolase|Cyclohydrolase]]
*[[Bifunctional purine biosynthesis protein PURH|Bifunctional purine biosynthesis protein PURH]]
*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: IMP cyclohydrolase]]
[[Category: Large Structures]]
[[Category: Ealick, S E]]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Kang, Y N]]
[[Category: Ealick SE]]
[[Category: Tran, A]]
[[Category: Kang YN]]
[[Category: White, R H]]
[[Category: Tran A]]
[[Category: Alpha-beta-beta-alpha ntn hydrolase fold]]
[[Category: White RH]]
[[Category: Hydrolase]]

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