2nsm: Difference between revisions

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OCA

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 ==Crystal structure of the human carboxypeptidase N (Kininase I) catalytic domain==
-<StructureSection load='2nsm' size='340' side='right' caption='[[2nsm]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='2nsm' size='340' side='right'caption='[[2nsm]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2nsm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NSM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2nsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NSM FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysine_carboxypeptidase Lysine carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.3 3.4.17.3] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsm OCA], [http://pdbe.org/2nsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nsm RCSB], [http://www.ebi.ac.uk/pdbsum/2nsm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsm ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nsm OCA], [https://pdbe.org/2nsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nsm RCSB], [https://www.ebi.ac.uk/pdbsum/2nsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nsm ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN]] Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:[http://omim.org/entry/212070 212070]]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.<ref>PMID:12560874</ref>
+[https://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN] Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:[https://omim.org/entry/212070 212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.<ref>PMID:12560874</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN]] Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
+[https://www.uniprot.org/uniprot/CBPN_HUMAN CBPN_HUMAN] Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 17: / Line 17: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ns/2nsm_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 33: / Line 33: @@
 ==See Also==
-*[[Carboxypeptidase|Carboxypeptidase]]
+*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Lysine carboxypeptidase]]
+[[Category: Large Structures]]
-[[Category: Bode, W]]
+[[Category: Bode W]]
-[[Category: Deddish, P A]]
+[[Category: Deddish PA]]
-[[Category: Erdoes, E G]]
+[[Category: Erdoes EG]]
-[[Category: Hoopes, J T]]
+[[Category: Hoopes JT]]
-[[Category: Huber, R]]
+[[Category: Huber R]]
-[[Category: Keil, C]]
+[[Category: Keil C]]
-[[Category: Maskos, K]]
+[[Category: Maskos K]]
-[[Category: Skidgel, R A]]
+[[Category: Skidgel RA]]
-[[Category: Tan, F]]
+[[Category: Tan F]]
-[[Category: Than, M]]
+[[Category: Than M]]
-[[Category: Caroxypeptidase]]
-[[Category: Hormone processing]]
-[[Category: Hydrolase]]
-[[Category: Peptide modification]]
-[[Category: Transthyretin-like domain]]
-[[Category: Zinc peptidase]]