2nt2: Difference between revisions
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==Crystal Structure of Slingshot phosphatase 2== | ==Crystal Structure of Slingshot phosphatase 2== | ||
<StructureSection load='2nt2' size='340' side='right' caption='[[2nt2]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2nt2' size='340' side='right'caption='[[2nt2]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2nt2]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2nt2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NT2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nt2 OCA], [https://pdbe.org/2nt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nt2 RCSB], [https://www.ebi.ac.uk/pdbsum/2nt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nt2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SSH2_HUMAN SSH2_HUMAN] Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.<ref>PMID:11832213</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Dual specificity phosphatase|Dual specificity phosphatase]] | *[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Jeong DG]] | ||
[[Category: | [[Category: Jung SK]] | ||
[[Category: Kim | [[Category: Kim JH]] | ||
[[Category: | [[Category: Kim SJ]] | ||
[[Category: | [[Category: Ryu SE]] | ||
[[Category: | [[Category: Yoon TS]] | ||