6ffy: Difference between revisions

No edit summary
No edit summary
 
Line 1: Line 1:


==Structure of the mouse SorCS2-NGF complex==
==Structure of the mouse SorCS2-NGF complex==
<StructureSection load='6ffy' size='340' side='right' caption='[[6ffy]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
<StructureSection load='6ffy' size='340' side='right'caption='[[6ffy]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ffy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FFY FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ffy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FFY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fg9|6fg9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sorcs2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Ngf, Ngfb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ffy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffy OCA], [https://pdbe.org/6ffy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ffy RCSB], [https://www.ebi.ac.uk/pdbsum/6ffy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ffy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffy OCA], [http://pdbe.org/6ffy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ffy RCSB], [http://www.ebi.ac.uk/pdbsum/6ffy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NGF_MOUSE NGF_MOUSE]] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
[https://www.uniprot.org/uniprot/SORC2_MOUSE SORC2_MOUSE]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 6ffy" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ffy" style="background-color:#fffaf0;"></div>
==See Also==
*[[Nerve growth factor|Nerve growth factor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Janssen, B J.C]]
[[Category: Mus musculus]]
[[Category: Leloup, N O.L]]
[[Category: Janssen BJC]]
[[Category: Apoptosis]]
[[Category: Leloup NOL]]
[[Category: Neuroplasticity]]
[[Category: P75ntr]]
[[Category: Prongf]]
[[Category: Sorcs2]]
[[Category: Sortilin]]
[[Category: Vps10]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA