2p0r: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2p0r.gif|left|200px]]


{{Structure
==Structure of Human Calpain 9 in complex with Leupeptin==
|PDB= 2p0r |SIZE=350|CAPTION= <scene name='initialview01'>2p0r</scene>, resolution 2.50&Aring;
<StructureSection load='2p0r' size='340' side='right'caption='[[2p0r]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
<table><tr><td colspan='2'>[[2p0r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_roseus Streptomyces roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P0R FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE= CAPN9, NCL4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AR7:AMINO{[(4S)-4-AMINO-5,5-DIHYDROXYPENTYL]AMINO}METHANIMINIUM'>AR7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0r OCA], [https://pdbe.org/2p0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p0r RCSB], [https://www.ebi.ac.uk/pdbsum/2p0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p0r ProSAT]</span></td></tr>
|RELATEDENTRY=[[1ziv|1ZIV]], [[2nqa|2NQA]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0r OCA], [http://www.ebi.ac.uk/pdbsum/2p0r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p0r RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CAN9_HUMAN CAN9_HUMAN] Calcium-regulated non-lysosomal thiol-protease.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p0/2p0r_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p0r ConSurf].
<div style="clear:both"></div>


'''Structure of Human Calpain 9 in complex with Leupeptin'''
==See Also==
 
*[[Calpain 3D structures|Calpain 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2P0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0R OCA].
[[Category: Calpain-1]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Streptomyces roseus]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Butler-Cole, C.]]
[[Category: Bochkarev A]]
[[Category: Davis, T L.]]
[[Category: Butler-Cole C]]
[[Category: Dhe-Paganon, S.]]
[[Category: Davis TL]]
[[Category: Edwards, A M.]]
[[Category: Dhe-Paganon S]]
[[Category: Jr., P J.Finerty.]]
[[Category: Edwards AM]]
[[Category: Paramanathan, R.]]
[[Category: Finerty Jr PJ]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Paramanathan R]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Walker, J R.]]
[[Category: Walker JR]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: alpha-beta protein]]
[[Category: calcium-dependent enzyme]]
[[Category: hydrolase]]
[[Category: inhibitor complex]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:26:25 2008''

Latest revision as of 11:26, 30 October 2024

Structure of Human Calpain 9 in complex with LeupeptinStructure of Human Calpain 9 in complex with Leupeptin

Structural highlights

2p0r is a 4 chain structure with sequence from Homo sapiens and Streptomyces roseus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAN9_HUMAN Calcium-regulated non-lysosomal thiol-protease.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2p0r, resolution 2.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2p0r&oldid=4196870"