2m6i: Difference between revisions

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OCA

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-{{Large structure}}
 ==Putative pentameric open-channel structure of full-length transmembrane domains of human glycine receptor alpha1 subunit==
-<StructureSection load='2m6i' size='340' side='right' caption='[[2m6i]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
+<StructureSection load='2m6i' size='340' side='right'caption='[[2m6i]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2m6i]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M6I FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2m6i]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M6I FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2m6b|2m6b]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m6i OCA], [http://pdbe.org/2m6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m6i RCSB], [http://www.ebi.ac.uk/pdbsum/2m6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m6i ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m6i OCA], [https://pdbe.org/2m6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m6i RCSB], [https://www.ebi.ac.uk/pdbsum/2m6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m6i ProSAT]</span></td></tr>
 </table>
-{{Large structure}}
+== Disease ==
+[https://www.uniprot.org/uniprot/GLRA1_HUMAN GLRA1_HUMAN] Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1) [MIM:[https://omim.org/entry/149400 149400]. A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.<ref>PMID:8298642</ref> [:]<ref>PMID:7925268</ref> <ref>PMID:7981700</ref> <ref>PMID:7881416</ref> <ref>PMID:7611730</ref> <ref>PMID:8571969</ref> <ref>PMID:8733061</ref> <ref>PMID:9067762</ref> <ref>PMID:10514101</ref> <ref>PMID:9920650</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/GLRA1_HUMAN GLRA1_HUMAN] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 24: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Cui, T]]
+[[Category: Large Structures]]
-[[Category: Jia, Y]]
+[[Category: Cui T]]
-[[Category: Ma, D]]
+[[Category: Jia Y]]
-[[Category: Makhov, A M]]
+[[Category: Ma D]]
-[[Category: Mowrey, D]]
+[[Category: Makhov AM]]
-[[Category: Tang, P]]
+[[Category: Mowrey D]]
-[[Category: Xu, Y]]
+[[Category: Tang P]]
-[[Category: Zhang, P]]
+[[Category: Xu Y]]
-[[Category: Anion channel]]
+[[Category: Zhang P]]
-[[Category: Glycine receptor]]
-[[Category: Membrane protein]]
-[[Category: Pentamer structure]]
-[[Category: Transmembrane domain]]