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==Ab initio crystal structure of Selenomethionine labelled Mycobacterium smegmatis Mfd== | |||
<StructureSection load='6ac6' size='340' side='right'caption='[[6ac6]], [[Resolution|resolution]] 2.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ac6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AC6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.989Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ac6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ac6 OCA], [https://pdbe.org/6ac6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ac6 RCSB], [https://www.ebi.ac.uk/pdbsum/6ac6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ac6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0R3C5_MYCS2 A0R3C5_MYCS2] Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.[HAMAP-Rule:MF_00969] | |||
==See Also== | |||
*[[Transcription-repair coupling factor 3D structures|Transcription-repair coupling factor 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mycolicibacterium smegmatis MC2 155]] | |||
[[Category: Fox GC]] | |||
[[Category: Nagaraja V]] | |||
[[Category: Natesh R]] | |||
[[Category: Putta S]] | |||
[[Category: Rao DN]] | |||
[[Category: Walsh MA]] | |||
Latest revision as of 12:41, 23 October 2024
Ab initio crystal structure of Selenomethionine labelled Mycobacterium smegmatis MfdAb initio crystal structure of Selenomethionine labelled Mycobacterium smegmatis Mfd
Structural highlights
FunctionA0R3C5_MYCS2 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.[HAMAP-Rule:MF_00969] See Also |
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