6h3h: Difference between revisions

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-'''Unreleased structure'''
-The entry 6h3h is ON HOLD  until Paper Publication
+==Fab fragment of antibody against fullerene C60==
+<StructureSection load='6h3h' size='340' side='right'caption='[[6h3h]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6h3h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6H3H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6h3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h3h OCA], [https://pdbe.org/6h3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6h3h RCSB], [https://www.ebi.ac.uk/pdbsum/6h3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6h3h ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure of the anti-C60 fullerene antibody Fab fragment (FabC60) was solved by X-ray crystallography. The computer-aided docking of C60 into the antigen-binding pocket of FabC60 showed that binding of C60 to FabC60 is governed by the enthalpy and entropy; namely, by pi-pi stacking interactions with aromatic residues of the antigen-binding site and reduction of the solvent-accessible area of the hydrophobic surface of C60. A fragment of the mobile CDR H3 loop located on the surface of FabC60 interferes with C60 binding in the antigen-binding site, thereby resulting in low antibody affinity for C60. The structure of apo-FabC60 has been deposited with pdbid 6H3H.
-Authors: Osipov, E.M., Tikhonova, T.V.
+Structure of the Anti-C60 Fullerene Antibody Fab Fragment: Structural Determinants of Fullerene Binding.,Osipov EM, Hendrickson OD, Tikhonova TV, Zherdev AV, Solopova ON, Sveshnikov PG, Dzantiev BB, Popov VO Acta Naturae. 2019 Jan-Mar;11(1):58-65. PMID:31024749<ref>PMID:31024749</ref>
-Description: Fab fragment of antibody against fullerene C60
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Osipov, E.M]]
+<div class="pdbe-citations 6h3h" style="background-color:#fffaf0;"></div>
-[[Category: Tikhonova, T.V]]
+==See Also==
+*[[Antibody 3D structures|Antibody 3D structures]]
+*[[Sandbox 20009|Sandbox 20009]]
+*[[3D structures of non-human antibody|3D structures of non-human antibody]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Osipov EM]]
+[[Category: Tikhonova TV]]