6e5p: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 6e5p is ON HOLD
+==Backbone model based on cryo-EM map at 8.5 A of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03==
+<SX load='6e5p' size='340' side='right' viewer='molstar' caption='[[6e5p]], [[Resolution|resolution]] 8.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e5p]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E5P FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900111:2alpha-alpha-mannobiose'>PRD_900111</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e5p OCA], [https://pdbe.org/6e5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e5p RCSB], [https://www.ebi.ac.uk/pdbsum/6e5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e5p ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447]  The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
-Authors: Acharya, P., Kwong, P.D.
+==See Also==
+*[[Antibody 3D structures|Antibody 3D structures]]
-Description: Cryo-EM structure of domain-swapped, glycan-reactive, neutralizing antibody 2G12 bound to HIV-1 Env BG505 DS-SOSIP, which was also bound to CD4-binding site antibody VRC03
+*[[Gp120 3D structures|Gp120 3D structures]]
-[[Category: Unreleased Structures]]
+__TOC__
-[[Category: Acharya, P]]
+</SX>
-[[Category: Kwong, P.D]]
+[[Category: Homo sapiens]]
+[[Category: Human immunodeficiency virus 1]]
+[[Category: Large Structures]]
+[[Category: Acharya P]]
+[[Category: Kwong PD]]