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==RDC refined high resolution structure of the third SH3 domain of CD2AP==
==RDC refined high resolution structure of the third SH3 domain of CD2AP==
<StructureSection load='2kro' size='340' side='right' caption='[[2kro]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2kro' size='340' side='right'caption='[[2kro]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KRO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRO FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jte|2jte]], [[2k9g|2k9g]], [[3krm|3krm]], [[3krn|3krn]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd2ap, Mets1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kro OCA], [https://pdbe.org/2kro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kro RCSB], [https://www.ebi.ac.uk/pdbsum/2kro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kro ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kro OCA], [http://pdbe.org/2kro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kro RCSB], [http://www.ebi.ac.uk/pdbsum/2kro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kro ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CD2AP_MOUSE CD2AP_MOUSE]] Required for cytokinesis (By similarity). Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.<ref>PMID:10514378</ref>
[https://www.uniprot.org/uniprot/CD2AP_MOUSE CD2AP_MOUSE] Required for cytokinesis (By similarity). Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.<ref>PMID:10514378</ref>  


==See Also==
==See Also==
*[[CD2-associated protein|CD2-associated protein]]
*[[CD2-associated protein 3D structures|CD2-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Azuaga, A I]]
[[Category: Mus musculus]]
[[Category: Blackledge, M]]
[[Category: Azuaga AI]]
[[Category: Nuland, N A.J van]]
[[Category: Blackledge M]]
[[Category: Roldan, J Ortega]]
[[Category: Ortega Roldan J]]
[[Category: Protein]]
[[Category: Van Nuland NAJ]]
[[Category: Sh3 domain]]
[[Category: Signaling protein]]

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