2k1b: Difference between revisions
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==Solution NMR structure of the chromo domain of the chromobox protein homolog 7== | ==Solution NMR structure of the chromo domain of the chromobox protein homolog 7== | ||
<StructureSection load='2k1b' size='340' side='right' caption='[[2k1b | <StructureSection load='2k1b' size='340' side='right'caption='[[2k1b]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k1b]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2k1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K1B FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1b OCA], [https://pdbe.org/2k1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1b RCSB], [https://www.ebi.ac.uk/pdbsum/2k1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1b ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Edwards | [[Category: Bountra C]] | ||
[[Category: Fares | [[Category: Edwards AM]] | ||
[[Category: Gutmanas | [[Category: Fares C]] | ||
[[Category: Kaustov | [[Category: Gutmanas A]] | ||
[[Category: Lemak | [[Category: Kaustov L]] | ||
[[Category: Loppnau | [[Category: Lemak A]] | ||
[[Category: Min | [[Category: Loppnau P]] | ||
[[Category: Quyang | [[Category: Min J]] | ||
[[Category: Ravichandran | [[Category: Quyang H]] | ||
[[Category: Ravichandran M]] | |||
[[Category: Weigelt | [[Category: Weigelt J]] | ||