2k0e: Difference between revisions
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==A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction== | ==A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction== | ||
<StructureSection load='2k0e' size='340' side='right' caption='[[2k0e | <StructureSection load='2k0e' size='340' side='right'caption='[[2k0e]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k0e]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2k0e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K0E FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k0e OCA], [https://pdbe.org/2k0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k0e RCSB], [https://www.ebi.ac.uk/pdbsum/2k0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k0e ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Calmodulin|Calmodulin]] | *[[Calmodulin 3D structures|Calmodulin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bui | [[Category: Large Structures]] | ||
[[Category: Cavalli | [[Category: Bui JM]] | ||
[[Category: Christodoulou | [[Category: Cavalli A]] | ||
[[Category: Dobson | [[Category: Christodoulou J]] | ||
[[Category: Gsponer | [[Category: Dobson CM]] | ||
[[Category: Richter | [[Category: Gsponer J]] | ||
[[Category: Vendruscolo | [[Category: Richter B]] | ||
[[Category: Vendruscolo M]] | |||