2j67: Difference between revisions

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 ==The TIR domain of human Toll-Like Receptor 10 (TLR10)==
-<StructureSection load='2j67' size='340' side='right' caption='[[2j67]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='2j67' size='340' side='right'caption='[[2j67]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2j67]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. The November 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J67 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2j67]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The November 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J67 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j67 OCA], [http://pdbe.org/2j67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j67 RCSB], [http://www.ebi.ac.uk/pdbsum/2j67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j67 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j67 OCA], [https://pdbe.org/2j67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j67 RCSB], [https://www.ebi.ac.uk/pdbsum/2j67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j67 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/TLR10_HUMAN TLR10_HUMAN] Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 30: @@
 ==See Also==
-*[[Toll-like Receptors|Toll-like Receptors]]
+*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: RCSB PDB Molecule of the Month]]
 [[Category: Toll-like Receptors]]
-[[Category: Arrowsmith, C]]
+[[Category: Arrowsmith C]]
-[[Category: Berg, S Van Den]]
+[[Category: Berglund H]]
-[[Category: Berglund, H]]
+[[Category: Busam R]]
-[[Category: Busam, R]]
+[[Category: Collins R]]
-[[Category: Collins, R]]
+[[Category: Edwards A]]
-[[Category: Edwards, A]]
+[[Category: Ericsson UB]]
-[[Category: Ericsson, U B]]
+[[Category: Flodin S]]
-[[Category: Flodin, S]]
+[[Category: Flores A]]
-[[Category: Flores, A]]
+[[Category: Graslund S]]
-[[Category: Graslund, S]]
+[[Category: Hallberg BM]]
-[[Category: Hallberg, B M]]
+[[Category: Hammarstrom M]]
-[[Category: Hammarstrom, M]]
+[[Category: Hogbom M]]
-[[Category: Hogbom, M]]
+[[Category: Holmberg Schiavone L]]
-[[Category: Johansson, I]]
+[[Category: Johansson I]]
-[[Category: Karlberg, T]]
+[[Category: Karlberg T]]
-[[Category: Kotenyova, T]]
+[[Category: Kotenyova T]]
-[[Category: Magnusdottir, A]]
+[[Category: Magnusdottir A]]
-[[Category: Nilsson, M E]]
+[[Category: Nilsson ME]]
-[[Category: Nilsson-Ehle, P]]
+[[Category: Nilsson-Ehle P]]
-[[Category: Nordlund, P]]
+[[Category: Nordlund P]]
-[[Category: Nyman, T]]
+[[Category: Nyman T]]
-[[Category: Ogg, D]]
+[[Category: Ogg D]]
-[[Category: Persson, C]]
+[[Category: Persson C]]
-[[Category: Sagemark, J]]
+[[Category: Sagemark J]]
-[[Category: Schiavone, L Holmberg]]
+[[Category: Stenmark P]]
-[[Category: Stenmark, P]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M]]
+[[Category: Thorsell AG]]
-[[Category: Thorsell, A G]]
+[[Category: Uppenberg J]]
-[[Category: Uppenberg, J]]
+[[Category: Van Den Berg S]]
-[[Category: Wallden, K]]
+[[Category: Wallden K]]
-[[Category: Weigelt, J]]
+[[Category: Weigelt J]]
-[[Category: Welin, M]]
+[[Category: Welin M]]
-[[Category: Glycoprotein]]
-[[Category: Il-1]]
-[[Category: Immune response]]
-[[Category: Inflammatory response]]
-[[Category: Innate immunity]]
-[[Category: Leucine-rich repeat]]
-[[Category: Membrane]]
-[[Category: Receptor]]
-[[Category: Tir]]
-[[Category: Tlr10]]
-[[Category: Toll]]
-[[Category: Toll-like receptor 10]]
-[[Category: Transmembrane]]