2j4i: Difference between revisions
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==CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX== | ==CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX== | ||
<StructureSection load='2j4i' size='340' side='right' caption='[[2j4i]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2j4i' size='340' side='right'caption='[[2j4i]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2j4i]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2j4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4I FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GSJ:1-PYRROLIDINEACETAMIDE,+3-[[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]AMINO]-ALPHA-METHYL-N-(1-METHYLETHYL)-N-[2-[(METHYLSULFONYL)AMINO]ETHYL]-2-OXO-,+(ALPHAS,3S)-'>GSJ</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GSJ:1-PYRROLIDINEACETAMIDE,+3-[[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]AMINO]-ALPHA-METHYL-N-(1-METHYLETHYL)-N-[2-[(METHYLSULFONYL)AMINO]ETHYL]-2-OXO-,+(ALPHAS,3S)-'>GSJ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4i OCA], [https://pdbe.org/2j4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4i RCSB], [https://www.ebi.ac.uk/pdbsum/2j4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4i ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Borthwick | [[Category: Large Structures]] | ||
[[Category: Brown | [[Category: Borthwick AD]] | ||
[[Category: Campbell | [[Category: Brown D]] | ||
[[Category: Chan | [[Category: Campbell M]] | ||
[[Category: Convery | [[Category: Chan C]] | ||
[[Category: Crowe | [[Category: Convery MA]] | ||
[[Category: Dayal | [[Category: Crowe MC]] | ||
[[Category: Diallo | [[Category: Dayal S]] | ||
[[Category: Kelly | [[Category: Diallo H]] | ||
[[Category: Kelly HA]] | |||
[[Category: Kleanthous | [[Category: Kleanthous S]] | ||
[[Category: Kurtis | [[Category: Kurtis CL]] | ||
[[Category: Mason | [[Category: Mason AM]] | ||
[[Category: Mordaunt | [[Category: Mordaunt JE]] | ||
[[Category: Patel | [[Category: Patel C]] | ||
[[Category: Pateman | [[Category: Pateman AJ]] | ||
[[Category: Senger | [[Category: Paul King N]] | ||
[[Category: Shah | [[Category: Senger S]] | ||
[[Category: Smith | [[Category: Shah GP]] | ||
[[Category: Watson | [[Category: Smith PW]] | ||
[[Category: Weston | [[Category: Watson NS]] | ||
[[Category: Young | [[Category: Weston HE]] | ||
[[Category: Zhou | [[Category: Young RJ]] | ||
[[Category: Zhou P]] | |||