2fz4: Difference between revisions

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 ==Crystal Structure of the N-terminal half of Archaeoglobus Fulgidus XPB==
-<StructureSection load='2fz4' size='340' side='right' caption='[[2fz4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='2fz4' size='340' side='right'caption='[[2fz4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2fz4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfu Arcfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FZ4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2fz4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FZ4 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAD25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fz4 OCA], [http://pdbe.org/2fz4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fz4 RCSB], [http://www.ebi.ac.uk/pdbsum/2fz4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fz4 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fz4 OCA], [https://pdbe.org/2fz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fz4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fz4 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/O29889_ARCFU O29889_ARCFU]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 17: / Line 19: @@
 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fz4 ConSurf].
 <div style="clear:both"></div>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-The human xeroderma pigmentosum group B (XPB) helicase is essential for transcription, nucleotide excision repair, and TFIIH functional assembly. Here, we determined crystal structures of an Archaeoglobus fulgidus XPB homolog (AfXPB) that characterize two RecA-like XPB helicase domains and discover a DNA damage recognition domain (DRD), a unique RED motif, a flexible thumb motif (ThM), and implied conformational changes within a conserved functional core. RED motif mutations dramatically reduce helicase activity, and the DRD and ThM, which flank the RED motif, appear structurally as well as functionally analogous to the MutS mismatch recognition and DNA polymerase thumb domains. Substrate specificity is altered by DNA damage, such that AfXPB unwinds dsDNA with 3' extensions, but not blunt-ended dsDNA, unless it contains a lesion, as shown for CPD or (6-4) photoproducts. Together, these results provide an unexpected mechanism of DNA unwinding with implications for XPB damage verification in nucleotide excision repair.
-Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.,Fan L, Arvai AS, Cooper PK, Iwai S, Hanaoka F, Tainer JA Mol Cell. 2006 Apr 7;22(1):27-37. PMID:16600867<ref>PMID:16600867</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 2fz4" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Arcfu]]
+[[Category: Archaeoglobus fulgidus DSM 4304]]
-[[Category: Fan, L]]
+[[Category: Large Structures]]
-[[Category: Tainer, J A]]
+[[Category: Fan L]]
-[[Category: Dna binding protein]]
+[[Category: Tainer JA]]
-[[Category: Dna damage recognition domain]]
-[[Category: Reca-like domain]]