6cdm: Difference between revisions

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 ==Structure of vaccine-elicited HIV-1 neutralizing antibody vFP7.04 in complex with HIV-1 fusion peptide residue 512-519==
-<StructureSection load='6cdm' size='340' side='right' caption='[[6cdm]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
+<StructureSection load='6cdm' size='340' side='right'caption='[[6cdm]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6cdm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CDM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6cdm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CDM FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tkj|5tkj]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.408&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cdm OCA], [http://pdbe.org/6cdm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cdm RCSB], [http://www.ebi.ac.uk/pdbsum/6cdm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cdm ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cdm OCA], [https://pdbe.org/6cdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cdm RCSB], [https://www.ebi.ac.uk/pdbsum/6cdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cdm ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q2N0S5_9HIV1 Q2N0S5_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292][SAAS:SAAS00139820]  The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.[SAAS:SAAS00140087]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 18: @@
 </div>
 <div class="pdbe-citations 6cdm" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Antibody 3D structures|Antibody 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Lk3 transgenic mice]]
+[[Category: Human immunodeficiency virus 1]]
-[[Category: Kwong, P D]]
+[[Category: Large Structures]]
-[[Category: Liu, K]]
+[[Category: Mus musculus]]
-[[Category: Xu, K]]
+[[Category: Kwong PD]]
-[[Category: Antibody]]
+[[Category: Liu K]]
-[[Category: Complex]]
+[[Category: Xu K]]
-[[Category: Fusion peptide]]
-[[Category: Immune system]]
-[[Category: Neutralizing]]