6b95: Difference between revisions
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==Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K== | ==Multiconformer model of K197C PTP1B tethered to compound 2 at 100 K== | ||
<StructureSection load='6b95' size='340' side='right' caption='[[6b95]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='6b95' size='340' side='right'caption='[[6b95]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6b95]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B95 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6b95]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B95 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D0P:~{N}-[5-[2,4-bis(fluoranyl)phenyl]-2-oxidanyl-phenyl]-2-sulfanyl-ethanamide'>D0P</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b95 OCA], [https://pdbe.org/6b95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b95 RCSB], [https://www.ebi.ac.uk/pdbsum/6b95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b95 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Biel JT]] | ||
[[Category: | [[Category: Brandao-Neto J]] | ||
[[Category: Fraser | [[Category: Fraser JS]] | ||
[[Category: Hill | [[Category: Hill ZB]] | ||
[[Category: Kang | [[Category: Kang E]] | ||
[[Category: Keedy | [[Category: Keedy DA]] | ||
[[Category: Rettenmaier | [[Category: Rettenmaier TJ]] | ||
[[Category: Wells | [[Category: Wells JA]] | ||
[[Category: | [[Category: Von Delft F]] | ||