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==The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state== | ==The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state== | ||
<StructureSection load='2ery' size='340' side='right' caption='[[2ery]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2ery' size='340' side='right'caption='[[2ery]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ery]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ery]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERY FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ery FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ery OCA], [https://pdbe.org/2ery PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ery RCSB], [https://www.ebi.ac.uk/pdbsum/2ery PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ery ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN] Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:[https://omim.org/entry/167000 167000]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN] It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 24: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith C]] | ||
[[Category: | [[Category: Burgess N]] | ||
[[Category: Doyle | [[Category: Doyle D]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Elkins | [[Category: Elkins J]] | ||
[[Category: Gileadi | [[Category: Gileadi C]] | ||
[[Category: Gileadi | [[Category: Gileadi O]] | ||
[[Category: Papagrigoriou | [[Category: Papagrigoriou E]] | ||
[[Category: Salah E]] | |||
[[Category: Salah | [[Category: Schoch G]] | ||
[[Category: Schoch | [[Category: Soundararajan M]] | ||
[[Category: Soundararajan | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Turnbull A]] | ||
[[Category: Turnbull | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Von Delft F]] | ||
[[Category: | |||
Latest revision as of 10:38, 23 August 2023
Structural highlights
DiseaseRRAS2_HUMAN Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. FunctionRRAS2_HUMAN It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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