2e3t: Difference between revisions

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==Crystal structure of rat xanthine oxidoreductase mutant (W335A and F336L)==
==Crystal structure of rat xanthine oxidoreductase mutant (W335A and F336L)==
<StructureSection load='2e3t' size='340' side='right' caption='[[2e3t]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='2e3t' size='340' side='right'caption='[[2e3t]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2e3t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E3T FirstGlance]. <br>
<table><tr><td colspan='2'>[[2e3t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E3T FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3t OCA], [http://pdbe.org/2e3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e3t RCSB], [http://www.ebi.ac.uk/pdbsum/2e3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3t ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e3t OCA], [https://pdbe.org/2e3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e3t RCSB], [https://www.ebi.ac.uk/pdbsum/2e3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e3t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/XDH_RAT XDH_RAT]] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.<ref>PMID:17301076</ref>
[https://www.uniprot.org/uniprot/XDH_RAT XDH_RAT] Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.<ref>PMID:17301076</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Xanthine dehydrogenase|Xanthine dehydrogenase]]
*[[Xanthine dehydrogenase 3D structures|Xanthine dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Asai, R]]
[[Category: Rattus norvegicus]]
[[Category: Matsumura, T]]
[[Category: Asai R]]
[[Category: Nishino, T]]
[[Category: Matsumura T]]
[[Category: Okamoto, K]]
[[Category: Nishino T]]
[[Category: Pai, E F]]
[[Category: Okamoto K]]
[[Category: Dehydrogenase to oxidase conversion]]
[[Category: Pai EF]]
[[Category: Oxidoreductase]]

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