2e1p: Difference between revisions

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==Crystal structure of pro-Tk-subtilisin==
==Crystal structure of pro-Tk-subtilisin==
<StructureSection load='2e1p' size='340' side='right' caption='[[2e1p]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2e1p' size='340' side='right'caption='[[2e1p]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2e1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_kodakaraensis_(strain_kod1) Pyrococcus kodakaraensis (strain kod1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E1P FirstGlance]. <br>
<table><tr><td colspan='2'>[[2e1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E1P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1p OCA], [http://pdbe.org/2e1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e1p RCSB], [http://www.ebi.ac.uk/pdbsum/2e1p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e1p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e1p OCA], [https://pdbe.org/2e1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e1p RCSB], [https://www.ebi.ac.uk/pdbsum/2e1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e1p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TKSU_THEKO TKSU_THEKO]] Has a broad substrate specificity with a slight preference to large hydrophobic amino acid residues at the P1 position.  
[https://www.uniprot.org/uniprot/TKSU_THEKO TKSU_THEKO] Has a broad substrate specificity with a slight preference to large hydrophobic amino acid residues at the P1 position.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/2e1p_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/2e1p_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Subtilisin|Subtilisin]]
*[[Subtilisin 3D structures|Subtilisin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Subtilisin]]
[[Category: Large Structures]]
[[Category: Chon, H]]
[[Category: Thermococcus kodakarensis KOD1]]
[[Category: Kanaya, S]]
[[Category: Chon H]]
[[Category: Koga, Y]]
[[Category: Kanaya S]]
[[Category: Matsumura, H]]
[[Category: Koga Y]]
[[Category: Saito, K]]
[[Category: Matsumura H]]
[[Category: Takano, K]]
[[Category: Saito K]]
[[Category: Tanaka, S]]
[[Category: Takano K]]
[[Category: Hydrolase]]
[[Category: Tanaka S]]
[[Category: Precursor]]
[[Category: Serine protease]]

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