2j05: Difference between revisions

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-[[Image:2j05.jpg|left|200px]]
- {{Structure
+==Crystal structure of the RasGAP SH3 domain at 1.5 Angstrom resolution==
-|PDB= 2j05 |SIZE=350|CAPTION= <scene name='initialview01'>2j05</scene>, resolution 1.50&Aring;
+<StructureSection load='2j05' size='340' side='right'caption='[[2j05]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+<table><tr><td colspan='2'>[[2j05]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J05 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-|GENE=
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wer|1wer]], [[1wq1|1wq1]], [[2j06|2j06]]</div></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j05 OCA], [https://pdbe.org/2j05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j05 RCSB], [https://www.ebi.ac.uk/pdbsum/2j05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j05 ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j05 OCA], [http://www.ebi.ac.uk/pdbsum/2j05 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j05 RCSB]</span>
+== Evolutionary Conservation ==
-}}
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
-'''CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION'''
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/2j05_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-==Overview==
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j05 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 X-ray structures of two crystal forms of the Src homology 3 domain (SH3) of the Ras GTPase activating protein (RasGAP) were determined at 1.5 and 1.8A resolution. The overall structure comprises a single domain with two tightly packed beta-sheets linked by a short helical segment. An important motif for peptide binding in other SH3 domains is not conserved in RasGAP. The RasGAP SH3 domain forms dimers in the crystal structures, which may provide new functional insight. The dimer interface involves residues also present in a peptide previously identified as an apoptotic sensitizer of tumor cells.
-==About this Structure==
+High resolution crystal structures of the p120 RasGAP SH3 domain.,Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:17188236<ref>PMID:17188236</ref>
-J05 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J05 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-High resolution crystal structures of the p120 RasGAP SH3 domain., Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M, Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17188236 17188236]
+</div>
-[[Category: Homo sapiens]]
+<div class="pdbe-citations 2j05" style="background-color:#fffaf0;"></div>
-[[Category: Single protein]]
-[[Category: Gajhede, M.]]
-[[Category: Kristensen, O.]]
-[[Category: Ross, B.]]
-[[Category: disease mutation]]
-[[Category: gtpase activating protein]]
-[[Category: gtpase activation]]
-[[Category: phosphorylation]]
-[[Category: proto-oncogene]]
-[[Category: ras signaling pathway]]
-[[Category: sh2 domain]]
-[[Category: sh3 domain]]
-[[Category: signal transduction]]
-[[Category: src homology 3]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:51:10 2008''
+==See Also==
+*[[Ras GTPase activating protein|Ras GTPase activating protein]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: Large Structures]]
+[[Category: Gajhede, M]]
+[[Category: Kristensen, O]]
+[[Category: Ross, B]]
+[[Category: Disease mutation]]
+[[Category: Gtpase activating protein]]
+[[Category: Gtpase activation]]
+[[Category: Phosphorylation]]
+[[Category: Proto-oncogene]]
+[[Category: Ras signaling pathway]]
+[[Category: Sh2 domain]]
+[[Category: Sh3 domain]]
+[[Category: Signal transduction]]
+[[Category: Src homology 3]]