Glycoprotein GP: Difference between revisions

Latest revision as of 13:01, 11 August 2021

Function

The virus contains a surface glycoprotein GP or envelope glycoprotein GP that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of GP1 and GP2 ^[1]. Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor. The GP2 subunit is thought to mediate membrane fusion.

For details see GP1 of Lassa Virus.

3D Structures of glycoprotein GP

Glycoprotein GP 3D structures

Ebolavirus glycosylated GP1 (wheat) and GP2 (blue) complex with antibody heavy chain (red) and light chain (aqua) (PDB code 3s88)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS. Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567

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Michal Harel

[1] Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS. Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567

[1]

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 == Function ==
-The virus contains a surface '''glycoprotein PG''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes.  GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>.  Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor.  The GP2 subunit is thought to mediate membrane fusion.
+The virus contains a surface '''glycoprotein GP''' or '''envelope glycoprotein GP''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes.  GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>.  Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor.  The GP2 subunit is thought to mediate membrane fusion.
 For details see [[GP1 of Lassa Virus]].
-== Disease ==
+== 3D Structures of glycoprotein GP ==
+[[Glycoprotein GP 3D structures]]
-== Relevance ==
-== Structural highlights ==
 </StructureSection>
-== 3D Structures of glycoprotein GP ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Glycoprotein GP
-**[[2wfo]] – MvGP1 – Machupo virus <br />
-**[[4zjf]] – GP1 – Lassa virus <br />
-**[[5nff]] – GP1 – Morogoro virus <br />
-**[[5nsj]] – GP1 – Whitewater arroyo mammarenavirus <br />
-**[[3lj5]], [[4v4k]] – GP1 – Bacteriophage p22 <br />
-**[[4n21]], [[4n23]] – GP2 ectodomain – CAS virus <br />
-*Glycoprotein GP complex
-**[[3ve0]], [[3s88]] – GP1 + GP2 + antibody – Sudan ebolavirus <br />
-**[[5f1b]] – ZevGP1 + GP2 + Niemann-Pick C1 protein – Zaire ebolavirus <br />
-**[[6f5u]], [[6f6i]], [[6f6n]], [[6f6s]] – ZevGP1 + GP2 + antidepressant <br />
-**[[3csy]], [[5kel]], [[5ken]] – ZevGP1 + GP2 + antibody <br />
-**[[5uqy]] – GP1 + GP2 + antibody – Marburg virus <br />
-**[[3kas]] – MvGP1 + transferrin receptor 1 <br />
-**[[5nuz]] – GP1 + antibody – Junin virus <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]