Glycerol-3-Phosphate Dehydrogenase: Difference between revisions
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===Function=== | ===Function=== | ||
GlpD functions in the intracellular membrane of E. coli and in the inner-mitochondrial membrane of eukaryotes. In E. Coli, GlpD catalyzes and reduces the reaction of dihydroxyacetone phosphate to glycerol 3-phosphate in the [http://www.pnas.org/content/105/9/3280/F1.large.jpg glycerol metabolism pathway]. The binding of the substrate analogues (glyceraldehydes 3-phosphate, glyceric acid 2-phosphate and phosphoenolpyruvate, dihydroxyacetone phosphate)or UQ substrate analogues (2-n-heptyl-4-hydroxyquinoline N-oxide and menadione). The conformational change of the structure and resiudes of GlpD catalyzes many different metabolic reactions. | GlpD functions in the intracellular membrane of E. coli and in the inner-mitochondrial membrane of eukaryotes. In E. Coli, GlpD catalyzes and reduces the reaction of dihydroxyacetone phosphate (DHAP) to glycerol 3-phosphate in the [http://www.pnas.org/content/105/9/3280/F1.large.jpg glycerol metabolism pathway]. The binding of the substrate analogues (glyceraldehydes 3-phosphate, glyceric acid 2-phosphate and phosphoenolpyruvate, dihydroxyacetone phosphate) or UQ substrate analogues (2-n-heptyl-4-hydroxyquinoline N-oxide and menadione). The conformational change of the structure and resiudes of GlpD catalyzes many different metabolic reactions. | ||
===Metabolic Pathways=== | ===Metabolic Pathways=== | ||
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====Phosphoplipid Biosynthesis==== | ====Phosphoplipid Biosynthesis==== | ||
GlpD reduces | GlpD reduces DHAP to glycerol 3-phosphate. Then the glycerol 3-phosphate is catalyzed by acyl transferase to 1-acylglyverol-3-phosphate, and then another acyl transferase catalyzes that to a phosphatidic acid. head groups are added to the phosphatidic acid to synthesize phospholipids. | ||
====Glyceroneogenesis==== | ====Glyceroneogenesis==== | ||
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GlpD is involved in diseases such as Alzeheimer`s, muscle dystrophy, hyaline membrane diseases and many more. | GlpD is involved in diseases such as Alzeheimer`s, muscle dystrophy, hyaline membrane diseases and many more. | ||
==3D structures of glycerol-3-phosphate dehydrogenase== | ==3D structures of glycerol-3-phosphate dehydrogenase== | ||
[[Glycerol-3-phosphate dehydrogenase 3D structures]] | |||
</StructureSection> | |||
==References== | ==References== | ||
<references /> | <references /> | ||