2dsq: Difference between revisions

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OCA

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 ==Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins==
-<StructureSection load='2dsq' size='340' side='right' caption='[[2dsq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+<StructureSection load='2dsq' size='340' side='right'caption='[[2dsq]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2dsq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DSQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2dsq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSQ FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wqj|1wqj]], [[2dsp|2dsp]], [[2dsr|2dsr]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsq OCA], [http://pdbe.org/2dsq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2dsq RCSB], [http://www.ebi.ac.uk/pdbsum/2dsq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsq ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsq OCA], [https://pdbe.org/2dsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsq RCSB], [https://www.ebi.ac.uk/pdbsum/2dsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsq ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
 == Function ==
-[[http://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[http://www.uniprot.org/uniprot/IBP1_HUMAN IBP1_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.<ref>PMID:15972819</ref>  [[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
+[https://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 16: / Line 14: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ds/2dsq_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 33: / Line 31: @@
 ==See Also==
 *[[Insulin-like growth factor|Insulin-like growth factor]]
-*[[Insulin-like growth factor binding protein|Insulin-like growth factor binding protein]]
+*[[Insulin-like growth factor binding protein 3D structures|Insulin-like growth factor binding protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Holak, T A]]
+[[Category: Large Structures]]
-[[Category: Huber, R]]
+[[Category: Holak TA]]
-[[Category: Popowicz, G M]]
+[[Category: Huber R]]
-[[Category: Sitar, T]]
+[[Category: Popowicz GM]]
-[[Category: Siwanowicz, I]]
+[[Category: Sitar T]]
-[[Category: Igf]]
+[[Category: Siwanowicz I]]
-[[Category: Igfbp]]
-[[Category: Insulin]]
-[[Category: Protein binding-hormone-growth factor complex]]