2iq1: Difference between revisions

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-[[Image:2iq1.gif|left|200px]]
- {{Structure
+==Crystal structure of human PPM1K==
-|PDB= 2iq1 |SIZE=350|CAPTION= <scene name='initialview01'>2iq1</scene>, resolution 2.250&Aring;
+<StructureSection load='2iq1' size='340' side='right'caption='[[2iq1]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+1'>AC1</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+<table><tr><td colspan='2'>[[2iq1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQ1 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-|GENE= DKFZp761G058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00143 PP2Cc]</span>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [https://pdbe.org/2iq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB], [https://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iq1 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2iq1 TOPSAN]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iq1 OCA], [http://www.ebi.ac.uk/pdbsum/2iq1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iq1 RCSB]</span>
+== Disease ==
-}}
+[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Intermediate maple syrup urine disease.
+== Function ==
+[https://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iq/2iq1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iq1 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of human PPM1K'''
+==See Also==
+*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
+== References ==
-==Overview==
+<references/>
-The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
+__TOC__
+</StructureSection>
-==About this Structure==
-IQ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQ1 OCA].
-==Reference==
-Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Adams, J.]]
+[[Category: Adams J]]
-[[Category: Almo, S C.]]
+[[Category: Almo SC]]
-[[Category: Bain, K T.]]
+[[Category: Bain KT]]
-[[Category: Bonanno, J B.]]
+[[Category: Bonanno JB]]
-[[Category: Burley, S K.]]
+[[Category: Burley SK]]
-[[Category: Freeman, J.]]
+[[Category: Freeman J]]
-[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
+[[Category: Pelletier L]]
-[[Category: Pelletier, L.]]
+[[Category: Russell M]]
-[[Category: Russell, M.]]
+[[Category: Sauder JM]]
-[[Category: Sauder, J M.]]
+[[Category: Wasserman S]]
-[[Category: Wasserman, S.]]
-[[Category: hydrolase]]
-[[Category: new york structural genomix research consortium]]
-[[Category: nysgxrc]]
-[[Category: protein phosphatase 2c kappa]]
-[[Category: protein structure initiative]]
-[[Category: psi-2]]
-[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:47:22 2008''