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==Crystal structure of the mercury-bound form of MerB mutant D99S==
==Crystal structure of the mercury-bound form of MerB mutant D99S==
<StructureSection load='5dsf' size='340' side='right' caption='[[5dsf]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='5dsf' size='340' side='right'caption='[[5dsf]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dsf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DSF FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dsf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DSF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.954&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3f0p|3f0p]], [[5c0t|5c0t]], [[5c0u|5c0u]], [[5c17|5c17]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">merB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsf OCA], [https://pdbe.org/5dsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dsf RCSB], [https://www.ebi.ac.uk/pdbsum/5dsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsf ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylmercury_lyase Alkylmercury lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.2 4.99.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dsf OCA], [http://pdbe.org/5dsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dsf RCSB], [http://www.ebi.ac.uk/pdbsum/5dsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dsf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MERB_ECOLX MERB_ECOLX]] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase (By similarity).  
[https://www.uniprot.org/uniprot/MERB_ECOLX MERB_ECOLX] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg(2+), which is subsequently detoxified by the mercuric reductase (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Alkylmercury lyase]]
[[Category: Large Structures]]
[[Category: Cappadocia, L]]
[[Category: Cappadocia L]]
[[Category: Lafrance-Vanasse, J]]
[[Category: Lafrance-Vanasse J]]
[[Category: Lecoq, L]]
[[Category: Lecoq L]]
[[Category: Mansour, A]]
[[Category: Mansour A]]
[[Category: Omichinski, J G]]
[[Category: Omichinski JG]]
[[Category: Stevenson, M]]
[[Category: Stevenson M]]
[[Category: Sygusch, J]]
[[Category: Sygusch J]]
[[Category: Wahba, H M]]
[[Category: Wahba HM]]
[[Category: Wilcox, D E]]
[[Category: Wilcox DE]]
[[Category: Wilkinson, K J]]
[[Category: Wilkinson KJ]]
[[Category: Lyase]]
[[Category: Metal binding protein]]

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