6fby: Difference between revisions

No edit summary
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Crystal structure of C-terminal modified Tau peptide-hybrid 4.2b with 14-3-3sigma==
==Crystal structure of C-terminal modified Tau peptide-hybrid 4.2b with 14-3-3sigma==
<StructureSection load='6fby' size='340' side='right' caption='[[6fby]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='6fby' size='340' side='right'caption='[[6fby]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fby]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FBY FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FBY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D4H:(2~{R})-2-[(~{S})-(3-methylphenyl)-phenyl-methyl]pyrrolidine'>D4H</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D4H:(2~{R})-2-[(~{S})-(3-methylphenyl)-phenyl-methyl]pyrrolidine'>D4H</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fau|6fau]], [[6fav|6fav]], [[6faw|6faw]], [[6fbw|6fbw]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fby OCA], [https://pdbe.org/6fby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fby RCSB], [https://www.ebi.ac.uk/pdbsum/6fby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fby ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fby OCA], [http://pdbe.org/6fby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fby RCSB], [http://www.ebi.ac.uk/pdbsum/6fby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fby ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity).  p53-regulated inhibitor of G2/M progression.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 17:
</div>
</div>
<div class="pdbe-citations 6fby" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fby" style="background-color:#fffaf0;"></div>
==See Also==
*[[Tau protein 3D structures|Tau protein 3D structures]]
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Andrei, S A]]
[[Category: Homo sapiens]]
[[Category: Meijer, F A]]
[[Category: Large Structures]]
[[Category: Milroy, L G]]
[[Category: Andrei SA]]
[[Category: Ottmann, C]]
[[Category: Meijer FA]]
[[Category: Structural protein]]
[[Category: Milroy LG]]
[[Category: Tau 14-3-3 alzheimer]]
[[Category: Ottmann C]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA