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| == Function == | | == Function == |
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| '''Dual specificity phosphatase''' (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> | | '''Dual specificity phosphatase''' or '''Dual specificity protein phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> |
| • '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br /> | | • '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br /> |
| • '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br /> | | • '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br /> |
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| == Structural highlights == | | == Structural highlights == |
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| <scene name='44/444621/Cv/5'>Tripeptide binding site</scene> in human Cdc14B2 (PDB code [[1ohe]]).<ref>PMID:12853468</ref> | | <scene name='44/444621/Cv/6'>Tripeptide binding site</scene> in human Cdc14B2 (PDB code [[1ohe]]).<ref>PMID:12853468</ref> |
| </StructureSection>
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| ==3D structures of dual specificity phosphatase== | | ==3D structures of dual specificity phosphatase== |
| | [[Dual specificity phosphatase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Dual specificity phosphatase
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| **[[4y2e]] – hDUSP 7 catalytic domain (mutant) - human<br />
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| **[[5xjv]] – hDUSP 13A (mutant) <br />
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| **[[4yr8]] – hDUSP 16 residues 156-301 + MAPK 8<br />
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| **[[4woh]] – hDUSP 22 (mutant) + nitrophenolphosphate<br />
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| **[[5gtj]] – hDUSP 26 (mutant) <br />
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| **[[5y15]], [[5y16]] – hDUSP 28 (mutant) <br />
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| *Slingshot phosphatase (SSH)
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| **[[2nt2]] – hSSH-2L catalytic domain - human<br />
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| *Phosphatase of regenerating liver (PRL)
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| **[[1xm2]] – hPRL-1 (mutant)<br />
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| **[[1zck]], [[1x24]] – rPRL-1 - rat<br />
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| **[[1zcl]] – rPRL-1 (mutant)<br />
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| **[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
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| *Cdc14
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| **[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br />
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| **[[1ohe]] – hCdc14B2 core domain + peptide<br />
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| *Cdc25
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| **[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />
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| **[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />
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| *Phosphoinositide phosphatase PTEN
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| **[[1d5r]], [[5bzz]], [[5bzx]], [[5bug]] – hPTEN (mutant)<br />
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| *Myotubularin-related protein (MTMR)
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| **[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant)<br />
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| **[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate<br />
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| **[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
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| **[[2yf0]] – hMTMR6<br />
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| *MAPK phosphatase see [[MAP kinase phosphatase]]
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |