6f6r: Difference between revisions
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==Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide== | ==Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide== | ||
<StructureSection load='6f6r' size='340' side='right' caption='[[6f6r]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='6f6r' size='340' side='right'caption='[[6f6r]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6f6r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F6R OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6f6r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F6R FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CVE:(3~{S})-3-[[(2~{R})-2-[3-methyl-2,6-bis(oxidanylidene)-5-[[4-(quinoxalin-2-ylamino)phenyl]carbonylamino]pyrimidin-1-yl]propanoyl]amino]-4-oxidanyl-butanoic+acid'>CVE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CVE:(3~{S})-3-[[(2~{R})-2-[3-methyl-2,6-bis(oxidanylidene)-5-[[4-(quinoxalin-2-ylamino)phenyl]carbonylamino]pyrimidin-1-yl]propanoyl]amino]-4-oxidanyl-butanoic+acid'>CVE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f6r OCA], [https://pdbe.org/6f6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f6r RCSB], [https://www.ebi.ac.uk/pdbsum/6f6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f6r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6f6r" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6f6r" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Caspase 3D structures|Caspase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Aubert | [[Category: Large Structures]] | ||
[[Category: Aurelly | [[Category: Aubert J]] | ||
[[Category: Bouix-Peter | [[Category: Aurelly M]] | ||
[[Category: Brethon | [[Category: Bouix-Peter C]] | ||
[[Category: Chambon | [[Category: Brethon A]] | ||
[[Category: Chantalat | [[Category: Chambon S]] | ||
[[Category: Christin | [[Category: Chantalat L]] | ||
[[Category: Clary | [[Category: Christin O]] | ||
[[Category: Comino | [[Category: Clary L]] | ||
[[Category: Dumais | [[Category: Comino C]] | ||
[[Category: El-Bazbouz | [[Category: Dumais L]] | ||
[[Category: Fournier | [[Category: El-Bazbouz G]] | ||
[[Category: Ghilini | [[Category: Fournier JF]] | ||
[[Category: Harris | [[Category: Ghilini AL]] | ||
[[Category: Hennequin | [[Category: Harris CS]] | ||
[[Category: Isabet | [[Category: Hennequin LF]] | ||
[[Category: Lardy | [[Category: Isabet T]] | ||
[[Category: Luzy | [[Category: Lardy C]] | ||
[[Category: Mathieu | [[Category: Luzy AP]] | ||
[[Category: Mebrouk | [[Category: Mathieu C]] | ||
[[Category: Millois-Barbuis | [[Category: Mebrouk K]] | ||
[[Category: Orfila | [[Category: Millois-Barbuis C]] | ||
[[Category: Pascau | [[Category: Orfila D]] | ||
[[Category: Pierre | [[Category: Pascau J]] | ||
[[Category: Reverse | [[Category: Pierre R]] | ||
[[Category: Roche | [[Category: Reverse K]] | ||
[[Category: Rodeschini | [[Category: Roche D]] | ||
[[Category: Talano | [[Category: Rodeschini V]] | ||
[[Category: Thoreau | [[Category: Talano S]] | ||
[[Category: Thoreau E]] | |||